dc.creator | Sepúlveda, Claudia Soledad | |
dc.creator | Fascio, Mirta Liliana | |
dc.creator | Mazzucco, María Belén | |
dc.creator | Docampo Palacios, Maite L. | |
dc.creator | Pellón, Rolando F. | |
dc.creator | Garcia, Cybele | |
dc.creator | D'accorso, Norma Beatriz | |
dc.creator | Damonte, Elsa Beatriz | |
dc.date.accessioned | 2019-03-08T20:10:14Z | |
dc.date.accessioned | 2022-10-15T05:19:03Z | |
dc.date.available | 2019-03-08T20:10:14Z | |
dc.date.available | 2022-10-15T05:19:03Z | |
dc.date.created | 2019-03-08T20:10:14Z | |
dc.date.issued | 2008-12 | |
dc.identifier | Sepúlveda, Claudia Soledad; Fascio, Mirta Liliana; Mazzucco, María Belén; Docampo Palacios, Maite L.; Pellón, Rolando F.; et al.; Synthesis and evaluation of N-substituted acridones as antiviral agents against haemorrhagic fever viruses; International Medical Press; Antiviral Chemistry & Chemotherapy; 19; 1; 12-2008; 41-47 | |
dc.identifier | 0956-3202 | |
dc.identifier | http://hdl.handle.net/11336/71284 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4348968 | |
dc.description.abstract | Background: In the present study, a series of N-substituted acridone derivatives was synthesized and evaluated against two haemorrhagic fever viruses (HFV). Methods: Compounds were tested against Junin virus (JUNV), an arenavirus agent of Argentine haemorrhagic fever, and dengue virus (DENV), a flavivirus agent of the most prevalent arthropod-borne viral disease in humans. Results: Among tested compounds, two N-allyl acridones (derivatives 3c and 3f) elicited a potent and selective antiviral activity against JUNV (strain IV4454) and DENV-2 (strain NGC) with 50% effective concentration values between 2.5 and 5.5 μM, as determined by virus yield inhibition. No cytotoxicity was detected at concentrations up to 1,000 μM, resulting in selectivity indices >181.8-400.0. Both acridones were effective against a wide spectrum of arenaviruses and the four serotypes of DENV. Furthermore, 3c and 3f failed to inactivate virus before cell infection as well as to induce a refractory state by cell pretreatment, indicating that the inhibitory effect was exerted through a blockade in virus multiplication during the infectious process. Conclusion: These data are the first demonstration that acridone derivatives have a potent antiviral activity that block in vitro multiplication of HFV belonging to Arenaviridae and Flaviviridae, such as JUNV and DENV. © 2008 International Medical Press. | |
dc.language | eng | |
dc.publisher | International Medical Press | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1177/095632020801900106 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.1177/095632020801900106 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | Junin Virus | |
dc.subject | Dengue Virus | |
dc.subject | Hemorrhagic Fever Viruses | |
dc.subject | Acridones | |
dc.title | Synthesis and evaluation of N-substituted acridones as antiviral agents against haemorrhagic fever viruses | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |