dc.creatorCaminero, Alberto
dc.creatorMcCarville, Justin L.
dc.creatorGalipeau, Heather J.
dc.creatorDeraison, Celine
dc.creatorBernier, Steve P.
dc.creatorConstante, Marco
dc.creatorRolland, Corinne
dc.creatorMeisel, Marlies
dc.creatorMurray, Joseph A.
dc.creatorYu, Xuechen B.
dc.creatorAlaedini, Armin
dc.creatorCoombes, Brian K.
dc.creatorBercik, Premysl
dc.creatorSouthward, Carolyn M.
dc.creatorRuf, Wolfram
dc.creatorJabri, Bana
dc.creatorChirdo, Fernando Gabriel
dc.creatorCasqueiro, Javier
dc.creatorSurette, Michael G.
dc.creatorVergnolle, Nathalie
dc.creatorVerdu, Elena F.
dc.date.accessioned2022-02-16T20:15:08Z
dc.date.accessioned2022-10-15T05:00:03Z
dc.date.available2022-02-16T20:15:08Z
dc.date.available2022-10-15T05:00:03Z
dc.date.created2022-02-16T20:15:08Z
dc.date.issued2019-03-13
dc.identifierCaminero, Alberto; McCarville, Justin L.; Galipeau, Heather J.; Deraison, Celine; Bernier, Steve P.; et al.; Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2; Nature Publishing Group; Nature Communications; 10; 1; 13-3-2019; 1-14
dc.identifier2041-1723
dc.identifierhttp://hdl.handle.net/11336/152154
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4347488
dc.description.abstractMicrobe-host interactions are generally homeostatic, but when dysfunctional, they can incite food sensitivities and chronic diseases. Celiac disease (CeD) is a food sensitivity characterized by a breakdown of oral tolerance to gluten proteins in genetically predisposed individuals, although the underlying mechanisms are incompletely understood. Here we show that duodenal biopsies from patients with active CeD have increased proteolytic activity against gluten substrates that correlates with increased Proteobacteria abundance, including Pseudomonas. Using Pseudomonas aeruginosa producing elastase as a model, we show gluten-independent, PAR-2 mediated upregulation of inflammatory pathways in C57BL/6 mice without villus blunting. In mice expressing CeD risk genes, P. aeruginosa elastase synergizes with gluten to induce more severe inflammation that is associated with moderate villus blunting. These results demonstrate that proteases expressed by opportunistic pathogens impact host immune responses that are relevant to the development of food sensitivities, independently of the trigger antigen.
dc.languageeng
dc.publisherNature Publishing Group
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41467-019-09037-9
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41467-019-09037-9
dc.rightshttps://creativecommons.org/licenses/by/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCeliac Dsease
dc.subjectMicrobiota
dc.subjectMucosal Immunity
dc.titleDuodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


Este ítem pertenece a la siguiente institución