dc.creatorGonzalez, Maria Ines
dc.creatorSanjuan, Norberto Aníbal
dc.date.accessioned2019-10-03T20:13:01Z
dc.date.accessioned2022-10-15T04:18:06Z
dc.date.available2019-10-03T20:13:01Z
dc.date.available2022-10-15T04:18:06Z
dc.date.created2019-10-03T20:13:01Z
dc.date.issued2013-07
dc.identifierGonzalez, Maria Ines; Sanjuan, Norberto Aníbal; Striated muscle involvement in experimental oral infection by herpes simplex virus type 1; Wiley Blackwell Publishing, Inc; Journal Of Oral Pathology And Medicine; 42; 6; 7-2013; 486-490
dc.identifier0904-2512
dc.identifierhttp://hdl.handle.net/11336/85173
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4344331
dc.description.abstractHerpes simplex virus type 1 is one of the most frequent causes of oral infection in humans, especially during early childhood. Several experimental models have been developed to study the pathogenesis of this virus but all of them employed adult animals. In this work, we developed an experimental model that uses mice younger than 4 days old, to more closely resemble human infection. Mice were infected subcutaneously with the prototype strain McIntyre of Herpes simplex-1, and the progression of infection was studied by immunoperoxidase. All animals died within 24-72 h post-infection, while viral antigens were found in the oral epithelium, nerves and brain. The most striking result was the finding of viral antigens in the nucleus and cytoplasm of cells belonging to striated muscles. Organotypic cultures of striated muscles were performed, and viral replication was observed in them by immunocytochemistry, electron microscopy and viral isolation. We conclude that the infection of striated muscles is present from the onset of oral infection and, eventually, could explain some clinical observations in humans.
dc.languageeng
dc.publisherWiley Blackwell Publishing, Inc
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/jop.12051
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/jop.12051
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHERPES SIMPLEX
dc.subjectINFECTION
dc.subjectMUSCLE
dc.subjectORAL
dc.subjectSTOMATITIS
dc.titleStriated muscle involvement in experimental oral infection by herpes simplex virus type 1
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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