First clinical isolation of an azole-resistant aspergillus fumigatus isolate harboring a TR46 Y121F T289A mutation in South America

dc.creatorIsla, Guillermina
dc.creatorLeonardelli, Florencia
dc.creatorTiraboschi, Iris Nora
dc.creatorRefojo, Nicolás
dc.creatorHevia, Alejandra
dc.creatorVivot, Walter Oscar
dc.creatorSzusz, Wanda
dc.creatorCórdoba, Susana Beatríz
dc.creatorGarcía Effron, Guillermo
dc.date.accessioned2019-11-25T13:16:19Z
dc.date.accessioned2022-10-15T04:17:51Z
dc.date.available2019-11-25T13:16:19Z
dc.date.available2022-10-15T04:17:51Z
dc.date.created2019-11-25T13:16:19Z
dc.date.issued2018-10
dc.identifierIsla, Guillermina; Leonardelli, Florencia; Tiraboschi, Iris Nora; Refojo, Nicolás; Hevia, Alejandra; et al.; First clinical isolation of an azole-resistant aspergillus fumigatus isolate harboring a TR46 Y121F T289A mutation in South America; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 62; 10; 10-2018; 1-7
dc.identifier0066-4804
dc.identifierhttp://hdl.handle.net/11336/89641
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4344305
dc.description.abstractOne of the most recently described Aspergillus fumigatus CYP51Amediated azole resistance mechanisms is TR46 Y121F T289A. Clinical A. fumigatus strains harboring these substitutions have been reported worldwide, with the exception of South America. We describe the first clinical A. fumigatus strain with this resistance mechanism isolated from an Argentinian patient. The strain was isolated in 2009 (1 year after the first-described mutant in United States), demonstrating that these alleles were scattered worldwide earlier than previously thought.
dc.languageeng
dc.publisherAmerican Society for Microbiology
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/lookup/doi/10.1128/AAC.00872-18
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/AAC.00872-18
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectASPERGILLUS FUMIGATUS
dc.subjectAZOLE
dc.subjectCYP51A
dc.subjectRESISTANCE
dc.subjectSOUTH AMERICA
dc.subjectTR46
dc.subjectTR46 Y121F T289A MUTATION
dc.titleFirst clinical isolation of an azole-resistant aspergillus fumigatus isolate harboring a TR46 Y121F T289A mutation in South America
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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