dc.creator | Sapochnik, Melanie Denise | |
dc.creator | Haedo, Mariana Raquel | |
dc.creator | Fuertes, Mariana | |
dc.creator | Ajler, Pablo | |
dc.creator | Carrizo, Guillermo | |
dc.creator | Cervio, Andrés | |
dc.creator | Sevlever, Gustavo | |
dc.creator | Stalla, Günter K. | |
dc.creator | Arzt, Eduardo Simon | |
dc.date.accessioned | 2018-12-06T13:20:50Z | |
dc.date.accessioned | 2022-10-15T04:05:09Z | |
dc.date.available | 2018-12-06T13:20:50Z | |
dc.date.available | 2022-10-15T04:05:09Z | |
dc.date.created | 2018-12-06T13:20:50Z | |
dc.date.issued | 2017-01 | |
dc.identifier | Sapochnik, Melanie Denise; Haedo, Mariana Raquel; Fuertes, Mariana; Ajler, Pablo; Carrizo, Guillermo; et al.; Autocrine IL-6 mediates pituitary tumor senescence; Impact Journals LLC; Oncotarget; 8; 3; 1-2017; 4690-4702 | |
dc.identifier | 1949-2553 | |
dc.identifier | http://hdl.handle.net/11336/65958 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4343352 | |
dc.description.abstract | Cellular senescence is a stable proliferative arrest state. Pituitary adenomas are frequent and mostly benign, but the mechanism for this remains unknown. IL-6 is involved in pituitary tumor progression and is produced by the tumoral cells. In a cell autonomous fashion, IL-6 participates in oncogene-induced senescence in transduced human melanocytes. Here we prove that autocrine IL-6 participates in pituitary tumor senescence. Endogenous IL-6 inhibition in somatotroph MtT/S shRNA stable clones results in decreased SA-β-gal activity and p16INK4a but increased pRb, proliferation and invasion. Nude mice injected with IL-6 silenced clones develop tumors contrary to MtT/S wild type that do not, demonstrating that clones that escape senescence are capable of becoming tumorigenic. When endogenous IL-6 is silenced, cell cultures derived from positive SA-β-gal human tumor samples decrease the expression of the senescence marker. Our results establish that IL-6 contributes to maintain senescence by its autocrine action, providing a natural model of IL-6 mediated benign adenoma senescence. | |
dc.language | eng | |
dc.publisher | Impact Journals LLC | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.18632/oncotarget.13577 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=13577&path[]=43122 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | AUTOCRINE | |
dc.subject | BENIGN TUMOR | |
dc.subject | IL-6 | |
dc.subject | PITUITARY TUMOR | |
dc.subject | SENESCENCE | |
dc.title | Autocrine IL-6 mediates pituitary tumor senescence | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |