dc.creatorDepino, Amaicha Mara
dc.date.accessioned2019-10-01T17:51:49Z
dc.date.accessioned2022-10-15T03:31:54Z
dc.date.available2019-10-01T17:51:49Z
dc.date.available2022-10-15T03:31:54Z
dc.date.created2019-10-01T17:51:49Z
dc.date.issued2015-07
dc.identifierDepino, Amaicha Mara; Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood; Pergamon-Elsevier Science Ltd; Neuroscience; 299; 7-2015; 56-65
dc.identifier0306-4522
dc.identifierhttp://hdl.handle.net/11336/84935
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4340394
dc.description.abstractMaternal immune activation can result in different behavioral abnormalities and brain dysfunction, depending on the nature of the inflammogen and the timing of the challenge. Few studies report the possible link between prenatal exposure to inflammation and mood disorders. Here we aimed to evaluate the effects of a single low lipopolysaccharide (LPS) injection to the dam at gestational day 9 on the offspring behavior and hippocampal function. We found that mice exposed to LPS show anxiety- and depression-related behaviors. Specifically, we found that animals prenatally exposed to LPS avoided the open arms of an elevated plus maze, the center of an open field and the lit side of a light/dark box, and they spent more time immobile in both the forced swimming and tail suspension tests, when compared with offspring of saline-injected dams. In addition, LPS mice had reduced serotonin and noradrenaline levels in the hippocampus and diminished Reelin immunoreactivity in the dentate gyrus, while their adult hippocampal neurogenesis was not affected. Results presented here support specific long-term effects of the response to a bacterial immunogen early in pregnancy, as opposed to different effects previously reported of viral immunogens and/or responses in late pregnancy. Our work adds to recent reports and stresses the relevance of considering prenatal exposure to a maternal immune response as a risk factor for mood disorders.
dc.languageeng
dc.publisherPergamon-Elsevier Science Ltd
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.neuroscience.2015.04.065
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0306452215004170
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectMATERNAL IMMUNE ACTIVATION
dc.subjectMOOD DISORDERS
dc.subjectNEUROGENESIS
dc.subjectREELIN
dc.subjectSEROTONIN
dc.titleEarly prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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