Efficacy of novel benznidazole solutions during the experimental infection with Trypanosoma cruzi

dc.creatorManarin, Romina
dc.creatorLamas, Maria Celina
dc.creatorBottasso, Emanuel
dc.creatorSerra, Esteban Carlos
dc.creatorRevelli, Silvia Susana
dc.creatorSalomon, Claudio Javier
dc.date.accessioned2020-12-03T20:01:21Z
dc.date.accessioned2022-10-15T03:28:01Z
dc.date.available2020-12-03T20:01:21Z
dc.date.available2022-10-15T03:28:01Z
dc.date.created2020-12-03T20:01:21Z
dc.date.issued2013-02
dc.identifierManarin, Romina; Lamas, Maria Celina; Bottasso, Emanuel; Serra, Esteban Carlos; Revelli, Silvia Susana; et al.; Efficacy of novel benznidazole solutions during the experimental infection with Trypanosoma cruzi; Elsevier Ireland; Parasitology International; 62; 1; 2-2013; 79-81
dc.identifier1383-5769
dc.identifierhttp://hdl.handle.net/11336/119786
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4340073
dc.description.abstractChagas' disease is caused by the protozoan parasite Trypanosoma cruzi. About 8. million people throughout Latin America are infected causing approximately 10,000 deaths annually. Benznidazole, available as unique 100. mg tablets in many of the endemic countries, is currently the drug of choice for the specific treatment of this condition. Despite of the large number of pediatric patients infected, there are no commercial liquid dosage forms available to treat this trypanosomiasis. This work showed that novel benznidazole-water-polyethylene glycol 400 solutions are active against T. cruzi in a murine model of Chagas' disease. Present results constitute the first demonstration on the usefulness of benznidazole solutions in infected mice.
dc.languageeng
dc.publisherElsevier Ireland
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.parint.2012.09.001
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1383576912001249
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBENZNIDAZOLE
dc.subjectCHAGAS' DISEASE
dc.subjectIN VIVO STUDIES
dc.subjectSOLUBLE FORMULATION
dc.titleEfficacy of novel benznidazole solutions during the experimental infection with Trypanosoma cruzi
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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