dc.creatorBueno Junior, Lezio
dc.creatorRuggiero, Rafael N.
dc.creatorRossignoli, Matheus T.
dc.creatorDel Bel, Elaine A.
dc.creatorLeite, Joao
dc.creatorUchitel, Osvaldo Daniel
dc.date.accessioned2019-01-08T20:06:33Z
dc.date.accessioned2022-10-15T03:16:59Z
dc.date.available2019-01-08T20:06:33Z
dc.date.available2022-10-15T03:16:59Z
dc.date.created2019-01-08T20:06:33Z
dc.date.issued2017-01-05
dc.identifierBueno Junior, Lezio; Ruggiero, Rafael N.; Rossignoli, Matheus T.; Del Bel, Elaine A.; Leite, Joao; et al.; Acetazolamide potentiates the afferent drive to prefrontal cortex in vivo; American Physiological Society; Physiological Reports; 5; 1; 5-1-2017; 1-7
dc.identifier2051-817X
dc.identifierhttp://hdl.handle.net/11336/67700
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4339131
dc.description.abstractThe knowledge on real-time neurophysiological effects of acetazolamide is still far behind the wide clinical use of this drug. Acetazolamide – a carbonic anhydrase inhibitor – has been shown to affect the neuromuscular transmission, implying a pH-mediated influence on the central synaptic transmission. To start filling such a gap, we chose a central substrate: hippocampal-prefrontal cortical projections; and a synaptic phenomenon: paired-pulse facilitation (a form of synaptic plasticity) to probe this drug's effects on interareal brain communication in chronically implanted rats. We observed that systemic acetazolamide potentiates the hippocampal-prefrontal paired-pulse facilitation. In addition to this field electrophysiology data, we found that acetazolamide exerts a net inhibitory effect on prefrontal cortical single-unit firing. We propose that systemic acetazolamide reduces the basal neuronal activity of the prefrontal cortex, whereas increasing the afferent drive it receives from the hippocampus. In addition to being relevant to the clinical and side effects of acetazolamide, these results suggest that exogenous pH regulation can have diverse impacts on afferent signaling across the neocortex.
dc.languageeng
dc.publisherAmerican Physiological Society
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.14814/phy2.13066
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.13066
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCARBONIC ANHYDRASE
dc.subjectHIPPOCAMPUS
dc.subjectPREFRONTAL CORTEX
dc.subjectSINGLE-UNIT ACTIVITY
dc.subjectSYNAPTIC PLASTICITY
dc.titleAcetazolamide potentiates the afferent drive to prefrontal cortex in vivo
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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