dc.creator | Salazar, Mario Oscar | |
dc.creator | Osella, Maria Ines | |
dc.creator | Ramallo, Ivana Ayelen | |
dc.creator | Furlan, Ricardo Luis Eugenio | |
dc.date.accessioned | 2020-07-16T17:05:08Z | |
dc.date.accessioned | 2022-10-15T03:00:37Z | |
dc.date.available | 2020-07-16T17:05:08Z | |
dc.date.available | 2022-10-15T03:00:37Z | |
dc.date.created | 2020-07-16T17:05:08Z | |
dc.date.issued | 2018-10 | |
dc.identifier | Salazar, Mario Oscar; Osella, Maria Ines; Ramallo, Ivana Ayelen; Furlan, Ricardo Luis Eugenio; N α -arylsulfonyl histamines as selective β-glucosidase inhibitors; Royal Society of Chemistry; RSC Advances; 8; 63; 10-2018; 36209-36218 | |
dc.identifier | 2046-2069 | |
dc.identifier | http://hdl.handle.net/11336/109406 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4337738 | |
dc.description.abstract | Nα-benzenesulfonylhistamine, a new semi-synthetic β-glucosidase inhibitor, was obtained by bioactivity-guided isolation from a chemically engineered extract of Urtica urens L. prepared by reaction with benzenesulfonyl chloride. In order to identify better β-glucosidase inhibitors, a new series of Nα,Nτ-di-arylsulfonyl and Nα-arylsulfonyl histamine derivatives was prepared. Biological studies revealed that the β-glucosidase inhibition was in a micromolar range for several Nα-arylsulfonyl histamine compounds of the series, Nα-4-fluorobenzenesulfonyl histamine being the most powerful compound. Besides, this reversible and competitive inhibitor presented a good selectivity for β-glucosidase with respect to other target enzymes including α-glucosidase. | |
dc.language | eng | |
dc.publisher | Royal Society of Chemistry | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1039/C8RA06625F | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2018/RA/C8RA06625F#!divAbstract | |
dc.rights | https://creativecommons.org/licenses/by/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Nα ARILSULFONYL HISTAMINE DERIVED | |
dc.subject | CHEMICALLY ENGINEERED EXTRACT | |
dc.subject | SULFONYLATION | |
dc.subject | GLUCOSIDASE | |
dc.title | N α -arylsulfonyl histamines as selective β-glucosidase inhibitors | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |