dc.creatorSalazar, Mario Oscar
dc.creatorOsella, Maria Ines
dc.creatorRamallo, Ivana Ayelen
dc.creatorFurlan, Ricardo Luis Eugenio
dc.date.accessioned2020-07-16T17:05:08Z
dc.date.accessioned2022-10-15T03:00:37Z
dc.date.available2020-07-16T17:05:08Z
dc.date.available2022-10-15T03:00:37Z
dc.date.created2020-07-16T17:05:08Z
dc.date.issued2018-10
dc.identifierSalazar, Mario Oscar; Osella, Maria Ines; Ramallo, Ivana Ayelen; Furlan, Ricardo Luis Eugenio; N α -arylsulfonyl histamines as selective β-glucosidase inhibitors; Royal Society of Chemistry; RSC Advances; 8; 63; 10-2018; 36209-36218
dc.identifier2046-2069
dc.identifierhttp://hdl.handle.net/11336/109406
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4337738
dc.description.abstractNα-benzenesulfonylhistamine, a new semi-synthetic β-glucosidase inhibitor, was obtained by bioactivity-guided isolation from a chemically engineered extract of Urtica urens L. prepared by reaction with benzenesulfonyl chloride. In order to identify better β-glucosidase inhibitors, a new series of Nα,Nτ-di-arylsulfonyl and Nα-arylsulfonyl histamine derivatives was prepared. Biological studies revealed that the β-glucosidase inhibition was in a micromolar range for several Nα-arylsulfonyl histamine compounds of the series, Nα-4-fluorobenzenesulfonyl histamine being the most powerful compound. Besides, this reversible and competitive inhibitor presented a good selectivity for β-glucosidase with respect to other target enzymes including α-glucosidase.
dc.languageeng
dc.publisherRoyal Society of Chemistry
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1039/C8RA06625F
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2018/RA/C8RA06625F#!divAbstract
dc.rightshttps://creativecommons.org/licenses/by/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNα ARILSULFONYL HISTAMINE DERIVED
dc.subjectCHEMICALLY ENGINEERED EXTRACT
dc.subjectSULFONYLATION
dc.subjectGLUCOSIDASE
dc.titleN α -arylsulfonyl histamines as selective β-glucosidase inhibitors
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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