dc.creatorSoldi, Natalia
dc.creatorFerella, Luciana
dc.creatorSchinder, Alejandro Fabián
dc.creatorPiatti, Veronica del Carmen
dc.date.accessioned2022-08-08T15:48:05Z
dc.date.accessioned2022-10-15T02:27:45Z
dc.date.available2022-08-08T15:48:05Z
dc.date.available2022-10-15T02:27:45Z
dc.date.created2022-08-08T15:48:05Z
dc.date.issued2020
dc.identifierWhen does the mammalian GPS use the dentate gyrus in everyday challenges of spatial navigation?; XXXIV Annual Meeting of the Argentine Society for Research in Neuroscience; Argentina; 2019; 1-2
dc.identifierhttp://hdl.handle.net/11336/164580
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4335067
dc.description.abstractOur mammalian GPS, Global Positioning System, is made of diverse brain structures such as the dentate gyrus (DG) of the hippocampus. This is one of the most plastic brain regions because it has adult neurogenesis and this process is modulated by the animal experiences.The most accepted function of the DG and its new neurons is the discrimination of similar spatial contexts. However, their contribution in an ordinary behaviour remains unknown. We started investigating the hypothesis that the DG would be necessary to solve difficult spatial challenges but not easy ones in a goal guided behaviour. Therefore, adult mice were infected with AAV flex-hM4Di plus CAG-Cre retrovirus in the DG to allow chemogenetic manipulation of neuronal activity in mice navigating in a crossword maze after the i. p. injection of the synthetic agonist clozapine-N-oxide (?CNO?) or its vehicle (?control?). In a single day mice had to learn two shortest paths to a new reward location. We designed spatial routes of two levels of cognitive demand and evaluated mice performance with or without chemogenetic inhibition (CNO vs. control). Easy and difficult journeys were equally solved and learnt by mice under control condition. However, mice receiving CNO could only learn easy spatial trajectories but not the difficult ones (p = 0.01, Wilcoxon signed rank test, N = 4 mice). Therefore, our preliminary data suggest that the DG is required by the GPS during spatial navigation in complex mnemonic challenges.
dc.languageeng
dc.publisherSAGE Publications
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/pdf/10.1177/1759091420979851
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/full/10.1177/1759091420979851
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1177/1759091420979851
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceASN Neuro
dc.subjectCROSSWORD MAZE
dc.subjecthM4Di
dc.subjectNOVELTY
dc.subjectCLOZAPINE-N-OXIDE
dc.titleWhen does the mammalian GPS use the dentate gyrus in everyday challenges of spatial navigation?
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typeinfo:eu-repo/semantics/conferenceObject
dc.typeinfo:ar-repo/semantics/documento de conferencia


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