dc.creatorTurino, Ludmila Noelia
dc.creatorStella, Barbara
dc.creatorDosio, Franco
dc.creatorLuna, Julio Alberto
dc.creatorBarresi, Antonello A.
dc.date.accessioned2019-10-21T16:17:19Z
dc.date.accessioned2022-10-15T02:09:52Z
dc.date.available2019-10-21T16:17:19Z
dc.date.available2022-10-15T02:09:52Z
dc.date.created2019-10-21T16:17:19Z
dc.date.issued2018-06
dc.identifierTurino, Ludmila Noelia; Stella, Barbara; Dosio, Franco; Luna, Julio Alberto; Barresi, Antonello A.; Nanoparticles obtained by confined impinging jet mixer: poly(lactide-co-glycolide) vs. Poly-ε-caprolactone; Taylor & Francis; Drug Development and Industrial Pharmacy; 44; 6; 6-2018; 934-941
dc.identifier0363-9045
dc.identifierhttp://hdl.handle.net/11336/86599
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4333685
dc.description.abstractThis paper is focused on the production and characterization of polymeric nanoparticles obtained by nanoprecipitation. The method consisted of using a confined impinging jet mixer (CIJM), circumventing high-energy equipment. Differences between the use of poly-ε-caprolactone (PCL) and poly(lactide-co-glycolide) (PLGA) as concerns particle mean size, zeta potential, and broad-spectrum antibiotic florfenicol entrapment were investigated. Other analyzed variables were polymer concentration, solvent, and anti-solvent flow rates, and antibiotic initial concentration. To our knowledge, no data were found related to PLGA and PCL nanoparticles comparison using CIJM. Also, florfenicol encapsulation within PCL or PLGA nanoparticles by nanoprecipitation has not been reported yet. The complexity of the nanoprecipitation phenomena has been confirmed, with many relevant variables involved in particles formation. PLGA resulted in smaller and more stable nanoparticles with higher entrapping of florfenicol than PCL.
dc.languageeng
dc.publisherTaylor & Francis
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/03639045.2017.1421662
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBIODEGRADABLE POLYMERS
dc.subjectNANOPRECIPITATION
dc.subjectNANOTECHNOLOGY
dc.subjectPCL
dc.subjectPLGA
dc.subjectPOLYMERIC DRUG CARRIERS
dc.titleNanoparticles obtained by confined impinging jet mixer: poly(lactide-co-glycolide) vs. Poly-ε-caprolactone
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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