dc.creator | Torres, María Luz | |
dc.creator | Oberti, Tamara Gisela | |
dc.creator | Fernández, Juan Manuel | |
dc.date.accessioned | 2021-09-08T18:53:39Z | |
dc.date.accessioned | 2022-10-15T01:15:48Z | |
dc.date.available | 2021-09-08T18:53:39Z | |
dc.date.available | 2022-10-15T01:15:48Z | |
dc.date.created | 2021-09-08T18:53:39Z | |
dc.date.issued | 2020-11-12 | |
dc.identifier | Torres, María Luz; Oberti, Tamara Gisela; Fernández, Juan Manuel; HEMA and alginate-based chondrogenic semi-interpenetrated hydrogels: Synthesis and biological bharacterization; Taylor & Francis; Journal of Biomaterials Science - Polymer Edition; 32; 4; 12-11-2020; 504-523 | |
dc.identifier | 0920-5063 | |
dc.identifier | http://hdl.handle.net/11336/139939 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4328949 | |
dc.description.abstract | Cartilage tissue engineering (CTE) has the general objective of restoring and improving damaged cartilage. A very interesting strategy of CTE is to combine different polymers to obtain a viscoelastic material. In the present study we have evaluated the applicability of Poly(2-hydroxyethyl methacrylate) networks semi-interpenetrated with sodium alginate for CTE. Alginate-containing hydrogels show an increase in scaffold porosity and swelling capacity, when compared with nonporous poly(2-hydroxyethyl methacrylate) scaffolds. Primary chondrocytes from young rats were cultured on the hydrogels, and an increase in chondrocyte proliferation and chondrocytic markers was observed in alginate-containing hydrogels. Chondrocytic phenotype was preserved on hydrogels containing the lowest amount of crosslinker and initiator (SEMI 3 and SEMI 4). In addition, Nitric oxide production by RAW264.7 macrophages grown on hydrogels was tested and none of the hydrogels showed high levels of this inflammatory marker after 2 days. These results indicate that our alginate-containing hydrogels could be useful for CTE. | |
dc.language | eng | |
dc.publisher | Taylor & Francis | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/09205063.2020.1849920 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1080/09205063.2020.1849920 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | SEMI-INTERPENETRATING POLYMER NETWORK | |
dc.subject | CHONDROCYTE | |
dc.subject | CHONDROCOMPATIBILITY | |
dc.subject | SWELLING | |
dc.subject | CONTACT ANGLE | |
dc.title | HEMA and alginate-based chondrogenic semi-interpenetrated hydrogels: Synthesis and biological bharacterization | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |