Cyclooxygenase-2 in testes of infertile men: Evidence for the induction of prostaglandin synthesis by interleukin-1β

dc.creatorMatzkin, Maria Eugenia
dc.creatorMayerhofer, Artur
dc.creatorRossi, Soledad Paola
dc.creatorGonzalez, Betina
dc.creatorGonzalez, Candela Rocio
dc.creatorGonzalez de Calvar, Silvia Ines
dc.creatorTerradas, Claudio
dc.creatorPonzio, Roberto Oscar
dc.creatorPuigdomenech, Elisa
dc.creatorLevalle, Oscar
dc.creatorCalandra, Ricardo Saul
dc.creatorFrungieri, Monica Beatriz
dc.date.accessioned2019-05-31T18:24:41Z
dc.date.accessioned2022-10-15T01:12:32Z
dc.date.available2019-05-31T18:24:41Z
dc.date.available2022-10-15T01:12:32Z
dc.date.created2019-05-31T18:24:41Z
dc.date.issued2010-10
dc.identifierMatzkin, Maria Eugenia; Mayerhofer, Artur; Rossi, Soledad Paola; Gonzalez, Betina; Gonzalez, Candela Rocio; et al.; Cyclooxygenase-2 in testes of infertile men: Evidence for the induction of prostaglandin synthesis by interleukin-1β; Elsevier Science Inc; Fertility and Sterility; 94; 5; 10-2010; 1933-1936
dc.identifier0015-0282
dc.identifierhttp://hdl.handle.net/11336/77475
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4328711
dc.description.abstractAs we previously reported, testes of men suffering from hypospermatogenesis and germ cell arrest or Sertoli cell-only syndrome show a major increase in the number of macrophages expressing interleukin-1β (IL-1β) and abundant expression of cyclooxygenase-2 (COX-2), the inducible isoform of the key enzyme in the biosynthesis of prostaglandins (PGs), in Leydig cells. In the present study we report [1] a positive correlation between IL-1β levels and COX-2 expression in testes of infertile patients, [2] the induction of COX-2 by IL-1β in mouse Leydig cells (TM3) and human macrophages (THP-1), and therefore [3] evidence for an IL-1β-dependent induction of testicular inflammatory states.
dc.languageeng
dc.publisherElsevier Science Inc
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0015028210000993
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.fertnstert.2010.01.039
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCox2
dc.subjectProstaglandins
dc.subjectInterleukin 1beta
dc.subjectTestis
dc.titleCyclooxygenase-2 in testes of infertile men: Evidence for the induction of prostaglandin synthesis by interleukin-1β
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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