Highlighting the interplay of microRNAs from Leishmania parasites and infected-host cells

Abstract

Leishmania parasites, the causative agents of leishmaniasis, are protozoan parasites with the ability to modify the signaling pathway and cell responses of their infected host cells. These parasite strategies alter the host cell environment and conditions favoring their replication, survival, and pathogenesis. Since microRNAs (miRNAs) are able to post-transcriptionally regulate gene expression processes, these biomolecules can exert critical roles in controlling Leishmania-host cell interplay. Therefore, the identification of relevant miRNAs differentially expressed in Leishmania parasites as well as in infected cells, which affect the host fitness, could be critical to understand the infection biology, pathogenicity, and immune response against these parasites. Accordingly, the current review aims to address the differentially expressed miRNAs in both, the parasite and infected host cells and how these biomolecules change cell signaling and host immune responses during infection. A deep understanding of these processes could provide novel guidelines and therapeutic strategies for managing and treating leishmaniasis.