Immune Mediators against Toxoplasma Gondii during Reactivation of Toxoplasmic Retinochoroiditis

dc.creatorRudzinski, Marcelo Nicolas
dc.creatorArgüelles, Carina
dc.creatorCouto, Cristóbal
dc.creatorOubiña, Jose Raul
dc.creatorReina, Silvia Lorena
dc.date.accessioned2022-05-06T13:54:39Z
dc.date.accessioned2022-10-15T00:21:33Z
dc.date.available2022-05-06T13:54:39Z
dc.date.available2022-10-15T00:21:33Z
dc.date.created2022-05-06T13:54:39Z
dc.date.issued2018-08
dc.identifierRudzinski, Marcelo Nicolas; Argüelles, Carina; Couto, Cristóbal; Oubiña, Jose Raul; Reina, Silvia Lorena; Immune Mediators against Toxoplasma Gondii during Reactivation of Toxoplasmic Retinochoroiditis; Taylor & Francis Ltd; Ocular Immunology And Inflammation; 27; 6; 8-2018; 949-957
dc.identifier0927-3948
dc.identifierhttp://hdl.handle.net/11336/156779
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4324214
dc.description.abstractPurpose: The purpose of this article is to analyze possible associations between systemic and ocular cytokine levels and specific clinical ophthalmologic signs from patients with a reactivation of toxoplasmic retinochoroiditis (RTR). Methods: A total of 18 patients with an active RTR episode, 8 patients with inactive scars, and 14 control patients were included in the study. Serum samples and aqueous humor (AH) samples were analyzed for IFN (interferon)-ã, interleukin (IL)-10, and IL-6 levels by ELISA. Inflammation grade, location, and size of the retinochoroidal active lesion, sampling time, and time to resolution were recorded. Results: A significantly negative correlation between AH and serum levels of IFN-ã was detected (p < 0.05). Patients with an AH IFN-ã/IL-10 ratio lower than 1 were associated with the longest time to resolution and/or severe complications. Conclusion: Serum IFN-ã levels may be used as a prognostic marker for both time to resolution and the development of possible severe complications during a given RTR episode.
dc.languageeng
dc.publisherTaylor & Francis Ltd
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/09273948.2018.1499940
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/09273948.2018.1499940
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectARGENTINA
dc.subjectIMMUNE RESPONSE
dc.subjectRETINOCHOROIDITIS
dc.subjectTOXOPLASMOSIS
dc.titleImmune Mediators against Toxoplasma Gondii during Reactivation of Toxoplasmic Retinochoroiditis
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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