dc.creator | Andreone, Luz | |
dc.creator | Velásquez, Ethel V. | |
dc.creator | Abramovich, Dalhia Nurit | |
dc.creator | Ambao, Veronica Ana | |
dc.creator | Loreti, Rosana Nazareth | |
dc.creator | Croxatto, Horacio B. | |
dc.creator | Parborell, Maria Fernanda Agustina | |
dc.creator | Tesone, Marta | |
dc.creator | Campo, Stella Maris | |
dc.date.accessioned | 2019-12-01T12:55:12Z | |
dc.date.accessioned | 2022-10-15T00:21:08Z | |
dc.date.available | 2019-12-01T12:55:12Z | |
dc.date.available | 2022-10-15T00:21:08Z | |
dc.date.created | 2019-12-01T12:55:12Z | |
dc.date.issued | 2009-10 | |
dc.identifier | Andreone, Luz; Velásquez, Ethel V.; Abramovich, Dalhia Nurit; Ambao, Veronica Ana; Loreti, Rosana Nazareth; et al.; Regulation of inhibin/activin expression in rat early antral follicles; Elsevier Ireland; Molecular and Cellular Endocrinology; 309; 1-2; 10-2009; 48-54 | |
dc.identifier | 0303-7207 | |
dc.identifier | http://hdl.handle.net/11336/91067 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4324171 | |
dc.description.abstract | The aim of the present study was to determine the endocrine activity of cultured early antral follicles (EAF) isolated from prepubertal diethylstilbestrol-treated rats. The effect of steroidogenic substrates and FSH on steroid, inhibin A and B, Pro-αC and activin A production was evaluated. Androsterone was the predominant steroid produced by EAF. The addition of androstenedione, androstenedione + FSH and progesterone stimulated oestradiol production, whereas 25-hydroxycholesterol (25-OH-Chol) increased progesterone production. Inhibin A, B, Pro-αC, and activin A were produced under basal conditions. The predominance of inhibin B over inhibin A was not affected by the addition of androstenedione or progesterone. Inhibin A and activin A production was stimulated by FSH. 25-OH-Chol increased Inha, Inhba and Inhbb mRNA expression and the production of the three molecular forms of inhibins but decreased activin A production. These results show that FSH and the steroid follicular microenvironment differentially modulate the gene expression of inhibin/activin subunits, their assembly and secretion. | |
dc.language | eng | |
dc.publisher | Elsevier Ireland | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S030372070900269X?via%3Dihub | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.mce.2009.05.003 | |
dc.relation | info:eu-repo/semantics/altIdentifier/pmid/https://www.ncbi.nlm.nih.gov/pubmed/19464342 | |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | 25-HYDROXYCHOLESTEROL | |
dc.subject | ACTIVIN | |
dc.subject | EARLY ANTRAL FOLLICLES | |
dc.subject | INHIBIN | |
dc.title | Regulation of inhibin/activin expression in rat early antral follicles | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |