dc.creatorAndreone, Luz
dc.creatorVelásquez, Ethel V.
dc.creatorAbramovich, Dalhia Nurit
dc.creatorAmbao, Veronica Ana
dc.creatorLoreti, Rosana Nazareth
dc.creatorCroxatto, Horacio B.
dc.creatorParborell, Maria Fernanda Agustina
dc.creatorTesone, Marta
dc.creatorCampo, Stella Maris
dc.date.accessioned2019-12-01T12:55:12Z
dc.date.accessioned2022-10-15T00:21:08Z
dc.date.available2019-12-01T12:55:12Z
dc.date.available2022-10-15T00:21:08Z
dc.date.created2019-12-01T12:55:12Z
dc.date.issued2009-10
dc.identifierAndreone, Luz; Velásquez, Ethel V.; Abramovich, Dalhia Nurit; Ambao, Veronica Ana; Loreti, Rosana Nazareth; et al.; Regulation of inhibin/activin expression in rat early antral follicles; Elsevier Ireland; Molecular and Cellular Endocrinology; 309; 1-2; 10-2009; 48-54
dc.identifier0303-7207
dc.identifierhttp://hdl.handle.net/11336/91067
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4324171
dc.description.abstractThe aim of the present study was to determine the endocrine activity of cultured early antral follicles (EAF) isolated from prepubertal diethylstilbestrol-treated rats. The effect of steroidogenic substrates and FSH on steroid, inhibin A and B, Pro-αC and activin A production was evaluated. Androsterone was the predominant steroid produced by EAF. The addition of androstenedione, androstenedione + FSH and progesterone stimulated oestradiol production, whereas 25-hydroxycholesterol (25-OH-Chol) increased progesterone production. Inhibin A, B, Pro-αC, and activin A were produced under basal conditions. The predominance of inhibin B over inhibin A was not affected by the addition of androstenedione or progesterone. Inhibin A and activin A production was stimulated by FSH. 25-OH-Chol increased Inha, Inhba and Inhbb mRNA expression and the production of the three molecular forms of inhibins but decreased activin A production. These results show that FSH and the steroid follicular microenvironment differentially modulate the gene expression of inhibin/activin subunits, their assembly and secretion.
dc.languageeng
dc.publisherElsevier Ireland
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S030372070900269X?via%3Dihub
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.mce.2009.05.003
dc.relationinfo:eu-repo/semantics/altIdentifier/pmid/https://www.ncbi.nlm.nih.gov/pubmed/19464342
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subject25-HYDROXYCHOLESTEROL
dc.subjectACTIVIN
dc.subjectEARLY ANTRAL FOLLICLES
dc.subjectINHIBIN
dc.titleRegulation of inhibin/activin expression in rat early antral follicles
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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