dc.creator | Pereyra, Armando Ezequiel | |
dc.creator | Mininni, Camilo Juan | |
dc.creator | Zanutto, Bonifacio Silvano | |
dc.date.accessioned | 2022-10-06T02:49:37Z | |
dc.date.accessioned | 2022-10-14T23:26:52Z | |
dc.date.available | 2022-10-06T02:49:37Z | |
dc.date.available | 2022-10-14T23:26:52Z | |
dc.date.created | 2022-10-06T02:49:37Z | |
dc.date.issued | 2021 | |
dc.identifier | Pereyra, Armando Ezequiel; Mininni, Camilo Juan; Zanutto, Bonifacio Silvano; Serotonergic modulation of basolateral amygdala nucleus in the extinction of reward-driven learning: The role of 5-HT bioavailability and 5-HT1A receptor; Elsevier Science; Behavioural Brain Research; 404; 2021; 1-10 | |
dc.identifier | 0166-4328 | |
dc.identifier | http://hdl.handle.net/11336/172105 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4319323 | |
dc.description.abstract | Serotonin (5-HT) neurotransmission has been associated with reward-related behaviour. Moreover, the serotonergic system modulates the basolateral amygdala (BLA), a structure involved in reward encoding, and reward prediction error. However, the role played by 5-HT on BLA during a reward-driven task has not been fully elucidated. In this paper, we investigated whether serotonergic modulation of the BLA is involved in reward-driven learning. To this end, we trained Long Evans rats in an operant conditioning task, and examined the effects of fluoxetine treatment (a selective serotonin reuptake inhibitor, 10 mg/kg) in combination with BLA lesions with NMDA (20 mg/mL) on extinction learning. We also investigated whether intra-BLA injection of the serotonergic 5-HT1A receptor agonist 8-OH DPAT, or antagonist WAY-100635, alters extinction performance. We found that fluoxetine treatment strongly accelerated extinction learning, while BLA lesions partially reverted this effect and slightly impaired consolidation of extinction. Stimulation and inhibition of 5-HT1A receptors in BLA induced opposite effects to those of fluoxetine, impairing or accelerating extinction performance, respectively. Our findings suggest that 5-HT modulates reward-driven learning, and 5-HT1A receptors located in the BLA are relevant for extinction. | |
dc.language | eng | |
dc.publisher | Elsevier Science | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0166432821000486 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbr.2021.113161 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | 5-HT1A | |
dc.subject | BASOLATERAL AMYGDALA | |
dc.subject | EXTINCTION | |
dc.subject | FLUOXETINE | |
dc.subject | OPERANT CONDITIONING | |
dc.subject | SEROTONIN | |
dc.subject | SEROTONERGIC | |
dc.subject | LEARNING | |
dc.title | Serotonergic modulation of basolateral amygdala nucleus in the extinction of reward-driven learning: The role of 5-HT bioavailability and 5-HT1A receptor | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |