dc.contributorSunil, Thomas
dc.creatorRupil, Lucia
dc.creatorSerradell, Marianela del Carmen.
dc.creatorLujan, Hugo Daniel
dc.date.accessioned2022-09-30T15:38:20Z
dc.date.accessioned2022-10-14T23:24:31Z
dc.date.available2022-09-30T15:38:20Z
dc.date.available2022-10-14T23:24:31Z
dc.date.created2022-09-30T15:38:20Z
dc.date.issued2022
dc.identifierRupil, Lucia; Serradell, Marianela del Carmen.; Lujan, Hugo Daniel; Production of Oral Vaccines Based on Retrovirus Virus-like Particles Pseudotyped with Protozoan-Surface Proteins; Springer Nature Switzerland AG; 2410; 2022; 503-537
dc.identifier978-1-07-161883-7
dc.identifierhttp://hdl.handle.net/11336/171250
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4319157
dc.description.abstractGiardia lamblia is the only known parasite that can inhabit the harsh upper gastrointestinal tract, wheremost of the digestive proteases are secreted. Intestinal and free-living protozoa express surface proteinscontaining an extraordinarily high percentage of cysteine. These cysteine-rich variant-specific surfaceproteins (VSPs) form a dense coat on the entire surface of Giardia trophozoites, that coat protects theparasite inside the host intestine. VSPs not only are resistant to proteolytic digestion, extreme pH andtemperatures, but also stimulate host immune responses. These properties can be used to protect as well asto increase the immunogenicity of vaccine antigens for oral administration. The incorporation of VSPs ontovirus-like particles bearing viral antigens allows oral administration of these vaccines, protecting theantigens from degradation and generating robust and protective immune responses. In this chapter wedescribe the development of this versatile vaccine platform for the generation of safe, stable, and efficientoral vaccines, including their production and validation, as well as the characterization of immune responseto oral immunization.
dc.languageeng
dc.publisherSpringer Nature Switzerland AG
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/book/10.1007/978-1-0716-1884-4?page=2#toc
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/978-1-0716-1884-4_26
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.sourceVaccine Design: Methods and Protocols. Vaccines for Human Diseases
dc.subjectORAL VACCINES
dc.subjectVIRUS LIKE PARTICLES
dc.subjectGIARDIA LAMBLIA
dc.subjectVARIANT SPECIFIC SURFACE PROTEINS
dc.titleProduction of Oral Vaccines Based on Retrovirus Virus-like Particles Pseudotyped with Protozoan-Surface Proteins
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typeinfo:eu-repo/semantics/bookPart
dc.typeinfo:ar-repo/semantics/parte de libro


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