dc.creator | Moreno, Griselda Noemí | |
dc.creator | Perello, Mario | |
dc.creator | Gaillard, Rolf C. | |
dc.creator | Spinedi, Eduardo Julio | |
dc.date.accessioned | 2021-10-16T17:13:42Z | |
dc.date.accessioned | 2022-10-14T23:22:55Z | |
dc.date.available | 2021-10-16T17:13:42Z | |
dc.date.available | 2022-10-14T23:22:55Z | |
dc.date.created | 2021-10-16T17:13:42Z | |
dc.date.issued | 2005-12 | |
dc.identifier | Moreno, Griselda Noemí; Perello, Mario; Gaillard, Rolf C.; Spinedi, Eduardo Julio; Orexin A stimulates hypothalamic-pituitary-adrenal (HPA) axis function, but not food intake, in the absence of full hypothalamic NPY-ergic activity; Humana Press; Endocrine; 26; 2; 12-2005; 99-106 | |
dc.identifier | 0969-711X | |
dc.identifier | http://hdl.handle.net/11336/143988 | |
dc.identifier | 1559-0100 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4318997 | |
dc.description.abstract | Neonatal monosodium L-glutamate (MSG) treatment destroys hypothalamic arcuate nucleus neuronal bodies, thus inducing several metabolic abnormalities. As a result, rats develop a phenotype characterized by hyperleptinemia and by impaired NPY but normal preproorexin hypothalamic mRNAs expression. Thus, our study was designed to explore whether hypothalamic effects of orexin A on food intake and glucocorticoid production develop in the absence of full hypothalamic NPY-ergic activity. For this purpose we evaluated, in control and MSG-treated rats, the consequences of intracerebroventricular (icv) orexin A administration on food intake and changes in circulating levels of ACTH and glucocorticoid. Our results indicate that orexin A icv treatment stimulated hypothalamic-pituitary-adrenal (HPA) axis activity in both MSG-damaged and normal animals, with this response even more pronounced in neurotoxin-damaged rats. Conversely, food intake was only enhanced by icv orexin A injection in normal rats. Our study further supports that acute hypothalamic effects of orexin A on food intake and glucocorticoid production are due to independent neuronal systems. While intact arcuate nucleus activity is needed for the orexinergic effect induced by icv orexin A administration, conversely, orexin A-stimulated HPA axis function takes place even in the absence of full NPY-ergic activity. | |
dc.language | eng | |
dc.publisher | Humana Press | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1385%2FENDO%3A26%3A2%3A099 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1385/ENDO:26:2:099 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | FOOD INTAKE | |
dc.subject | HYPOTHALAMIC OBESITY | |
dc.subject | LEPTIN | |
dc.subject | MSG | |
dc.subject | OREXINERGIC PATHWAYS | |
dc.subject | STRESS HORMONES | |
dc.title | Orexin A stimulates hypothalamic-pituitary-adrenal (HPA) axis function, but not food intake, in the absence of full hypothalamic NPY-ergic activity | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |