dc.creator | Acosta , Helena | |
dc.creator | Lopez, Silvia Liliana | |
dc.creator | Revinski, Diego Raul | |
dc.creator | Carrasco, Andres Eduardo | |
dc.date.accessioned | 2019-01-02T21:55:18Z | |
dc.date.accessioned | 2022-10-14T22:32:51Z | |
dc.date.available | 2019-01-02T21:55:18Z | |
dc.date.available | 2022-10-14T22:32:51Z | |
dc.date.created | 2019-01-02T21:55:18Z | |
dc.date.issued | 2011-06 | |
dc.identifier | Acosta , Helena; Lopez, Silvia Liliana; Revinski, Diego Raul; Carrasco, Andres Eduardo; Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus; Company of Biologists; Development; 138; 12; 6-2011; 2567-2579 | |
dc.identifier | 0950-1991 | |
dc.identifier | http://hdl.handle.net/11336/67259 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4314440 | |
dc.description.abstract | The blastula chordin- and noggin-expressing centre (BCNE) is the predecessor of the Spemann-Mangold's organiser and alsocontains the precursors of the brain. This signalling centre comprises animal-dorsal and marginal-dorsal cells and appears as a consequence of the nuclear accumulation of β-catenin on the dorsal side. Here, we propose a role for Notch that was not previously explored during early development in vertebrates. Notch initially destabilises β-catenin in a process that does not depend on its phosphorylation by GSK3. This is important to restrict the BCNE to its normal extent and to control the size of the brain. © 2011. Published by The Company of Biologists Ltd. | |
dc.language | eng | |
dc.publisher | Company of Biologists | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1242/dev.061143 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://dev.biologists.org/content/138/12/2567 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Β-CATENIN | |
dc.subject | BCNE | |
dc.subject | BRAIN | |
dc.subject | DORSAL-ANTERIOR DEVELOPMENT | |
dc.subject | NOTCH | |
dc.subject | XENOPUS | |
dc.title | Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |