Beneficial lactobacilli: Effects on the vaginal tract in a murine experimental model

dc.creatorde Gregorio, Priscilla Romina
dc.creatorJuárez Tomás, María Silvina
dc.creatorSantos, Viviana
dc.creatorNader, Maria Elena Fatima
dc.date2012-11
dc.identifierhttp://hdl.handle.net/11336/78283
dc.identifierde Gregorio, Priscilla Romina; Juárez Tomás, María Silvina; Santos, Viviana; Nader, Maria Elena Fatima; Beneficial lactobacilli: Effects on the vaginal tract in a murine experimental model; Springer; Antonie van Leeuwenhoek; 102; 4; 11-2012; 569-580
dc.identifier0003-6072
dc.identifier1572-9699
dc.identifierCONICET Digital
dc.identifierCONICET
dc.descriptionVaginal probiotics containing lactic acid bacteria with activity towards pathogenic microorganisms that cause urogenital tract infections have been proposed as a valid strategy for their prophylaxis and therapy. A murine experimental model was set up to evaluate the colonization capability of beneficial human lactobacilli and their effects on the mouse vaginal mucosa and innate immune cells. Five Lactobacillus strains were intravaginally inoculated into previously estrogenized BALB/c mice. The significance of the effects observed in the vaginal tract was determined by analysis of variance using the general linear model. The numbers of viable vaginal lactobacilli were significantly higher at proestrous-estrous than those at the metaestrous-diestrous phase and decreased markedly on the days after inoculation. Lactobacilli inoculation did not cause cytological or histological modifications of the murine vaginal tract. Moreover, the intravaginal administration of Lactobacillus salivarius CRL (Centro de Referencia para Lactobacilos culture collection) 1328 and Lactobacillus gasseri CRL 1263 did not affect the amounts of granulocytes and macrophages present in vaginal washings. In conclusion, the results demonstrate that vaginal lactobacilli did not produce adverse effects on the murine vaginal tract. Therefore, they could be proposed as safe probiotic candidates to promote a balanced microbiota in the urogenital tract.
dc.descriptionFil: de Gregorio, Priscilla Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.descriptionFil: Juárez Tomás, María Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
dc.descriptionFil: Santos, Viviana. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Orgánica; Argentina
dc.descriptionFil: Nader, Maria Elena Fatima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
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dc.languageeng
dc.publisherSpringer
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1007/s10482-012-9752-9
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs10482-012-9752-9
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subjectLactobacillus Vaginal Colonization
dc.subjectMouse Experimental Model
dc.subjectUrogenital Probiotic Candidates
dc.subjectVaginal Innate Immune Cells
dc.subjecthttps://purl.org/becyt/ford/3.4
dc.subjecthttps://purl.org/becyt/ford/3
dc.titleBeneficial lactobacilli: Effects on the vaginal tract in a murine experimental model
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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