Neurotensin inhibits neuronal Na+, K+-ATPase activity through high affinity peptide receptor

dc.creatorLópez Ordieres, María Graciela
dc.creatorRodriguez, Georgina Emma
dc.date2000-03
dc.identifierhttp://hdl.handle.net/11336/39162
dc.identifierLópez Ordieres, María Graciela; Rodriguez, Georgina Emma; Neurotensin inhibits neuronal Na+, K+-ATPase activity through high affinity peptide receptor; Elsevier Science Inc; Peptides; 21; 4; 3-2000; 571-576
dc.identifier0196-9781
dc.identifierCONICET Digital
dc.identifierCONICET
dc.descriptionNeurotensin is a peptide present in mammalian CNS and peripheral tissues, which may play a major role in neurotransmission or neuromodulation, subserving diverse physiological functions. We studied the effect of added neurotensin on ATPase activities in synaptosomal membranes isolated from rat cerebral cortex. Neurotensin at 3 x 10-8-3 x 10-6 M concentration decreased 20-44% Na+, K+-ATPase activity but failed to modify Mg2+-ATPase activity; lower neurotensin concentrations (3 x 10-14-3 x 10-10 M) had no effect on enzyme activities. This inhibitory effect was abolished by neurotensin heating, by enzyme preincubation with neurotensin during periods exceeding 10 min, or by adding 1 x 10-6 M SR 48692, a high affinity neurotensin receptor antagonist. Levocabastine, which blocks low affinity neurotensin receptor, failed to alter enzyme inhibition by the peptide. It is suggested that the sodium pump may be a target for neurotensin effects at neuronal level involving the participation of high affinity neurotensin receptor. © 2000 Elsevier Science Inc.
dc.descriptionFil: López Ordieres, María Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; Argentina
dc.descriptionFil: Rodriguez, Georgina Emma. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; Argentina
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dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier Science Inc
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://europepmc.org/abstract/med/10822114
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1016/S0196-9781(00)00183-2
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subjectAtpases
dc.subjectK+-Atpase
dc.subjectNa+
dc.subjectNeurotensin Effect
dc.subjectNeurotensin Receptor
dc.subjectSynaptosomal Membrane Enzymes
dc.subjecthttps://purl.org/becyt/ford/3.1
dc.subjecthttps://purl.org/becyt/ford/3
dc.titleNeurotensin inhibits neuronal Na+, K+-ATPase activity through high affinity peptide receptor
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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