Characterization of pituitary cell populations in rats with induced polycystic ovaries

dc.creatorFrancou, María Manuela
dc.creatorDurdos, Mauro
dc.creatorSalvetti, Natalia Raquel
dc.creatorBaravalle, Celina
dc.creatorRey, Florencia
dc.creatorOrtega, Hugo Hector
dc.date2008-03
dc.identifierhttp://hdl.handle.net/11336/114115
dc.identifierFrancou, María Manuela; Durdos, Mauro; Salvetti, Natalia Raquel; Baravalle, Celina; Rey, Florencia; et al.; Characterization of pituitary cell populations in rats with induced polycystic ovaries; Karger; Cells Tissues Organs; 188; 3; 3-2008; 310-319
dc.identifier1422-6405
dc.identifierCONICET Digital
dc.identifierCONICET
dc.descriptionSeveral hypotheses have been proposed about the pathogenesis of polycystic ovarian syndrome (PCOS), however, the fundamental physiological interactions that initiate the development of follicular cysts have not yet been elucidated. Hence, in this study the proliferation, density and population of gonadotrophs, mammotrophs, somatotrophs and corticotrophs of the pituitary glands of rats with induced follicular cysts have been investigated by 2 experimental models (continuous light exposition and estradiol valerate-treated rats). Specific immunoreactivity associated with follicle-stimulating hormone, luteinizing hormone, prolactin, growth hormone and adrenocorticotropic hormone was evaluated by immunohistochemistry with specific hormone antibodies and proliferation of secretory cells by their colocalization (double-labeling) with proliferating cell nuclear antigen. The results indicate a reduction in the density and proliferation of gonadotrophs in both experimental groups. A reduction in the average density, proliferation and population of lactotrophs and corticotrophs was also observed in estradiol valerate-treated animals. However, no significant differences were found in somatotrophs. The present study contributes to the information about alterations of some cell populations that occur in the pituitary gland of rats with polycystic ovaries, and will enhance our understanding of the pathogenesis of this disease.
dc.descriptionFil: Francou, María Manuela. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular; Argentina
dc.descriptionFil: Durdos, Mauro. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Ciencias Morfológicas. Laboratorio de Biología Celular y Molecular; Argentina
dc.descriptionFil: Salvetti, Natalia Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
dc.descriptionFil: Baravalle, Celina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
dc.descriptionFil: Rey, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
dc.descriptionFil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina
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dc.languageeng
dc.publisherKarger
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://content.karger.com/produktedb/produkte.asp?DOI=000123202&typ=pdf
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1159/000123202
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subjectPITUITARY
dc.subjectPOLYCYSTIC OVARIES
dc.subjectRAT
dc.subjecthttps://purl.org/becyt/ford/4.3
dc.subjecthttps://purl.org/becyt/ford/4
dc.titleCharacterization of pituitary cell populations in rats with induced polycystic ovaries
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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