dc.creator | Bizzozzero Hiriart, Marianne | |
dc.creator | Di Giorgio, Noelia Paula | |
dc.creator | Libertun, Carlos | |
dc.creator | Lux, Victoria Adela R. | |
dc.date.accessioned | 2022-06-21T19:21:31Z | |
dc.date.accessioned | 2022-10-14T21:51:59Z | |
dc.date.available | 2022-06-21T19:21:31Z | |
dc.date.available | 2022-10-14T21:51:59Z | |
dc.date.created | 2022-06-21T19:21:31Z | |
dc.date.issued | 2021-12 | |
dc.identifier | Bizzozzero Hiriart, Marianne; Di Giorgio, Noelia Paula; Libertun, Carlos; Lux, Victoria Adela R.; GABAB receptor antagonism from birth to weaning permanently modifies Kiss1 expression in hypothalamus and gonads in mice; Karger; Neuroendocrinology; 12-2021; 1-28 | |
dc.identifier | 0028-3835 | |
dc.identifier | http://hdl.handle.net/11336/160105 | |
dc.identifier | 1423-0194 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4310716 | |
dc.description.abstract | The kisspeptin gene Kiss1 is expressed in two hypothalamic areas: anteroventral periventricular nucleus/periventricular nucleus (AVPV/PeN) and arcuate nucleus (ARC), and also in gonads. Several pieces of evidence suggests that gamma-amino butyric acid B receptors (GABAB) signaling can regulate Kiss1 expression. Here, we inhibited GABAB signaling from PND2 to PND21 and evaluated the hypothalamic-pituitary-gonadal (HPG) axis. Methods: BALB/c mice were treated on postnatal days 2–21 (PND2–PND21) with CGP55845 (GABAB antagonist) and evaluated in PND21 and adulthood: gene expression (qPCR) in the hypothalamus and gonads, hormones by radioimmunoassay, gonad histochemistry (H&E), puberty onset, and estrous cycles. | |
dc.language | eng | |
dc.publisher | Karger | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/FullText/521649 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1159/000521649 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | GAMMA-AMINO BUTYRIC ACID | |
dc.subject | GAMMA-AMINO BUTYRIC ACID B RECEPTORS | |
dc.subject | KISS1 | |
dc.subject | GONADOTROPINS | |
dc.subject | SEX STEROIDS | |
dc.title | GABAB receptor antagonism from birth to weaning permanently modifies Kiss1 expression in hypothalamus and gonads in mice | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |