Multicomponent Click Synthesis of 1,2,3-Triazoles from Epoxides in Water Catalyzed by Copper Nanoparticles on Activated Carbon

dc.creatorAlonso, Francisco
dc.creatorMoglie, Yanina Fernanda
dc.creatorRadivoy, Gabriel Eduardo
dc.creatorYus, Miguel
dc.date2011-09-06
dc.identifierhttp://hdl.handle.net/11336/157179
dc.identifierAlonso, Francisco; Moglie, Yanina Fernanda; Radivoy, Gabriel Eduardo; Yus, Miguel; Multicomponent Click Synthesis of 1,2,3-Triazoles from Epoxides in Water Catalyzed by Copper Nanoparticles on Activated Carbon; American Chemical Society; Journal of Organic Chemistry; 76; 20; 6-9-2011; 8394-8405
dc.identifier0022-3263
dc.identifierCONICET Digital
dc.identifierCONICET
dc.descriptionCopper nanoparticles on activated carbon have been found to effectively catalyze the multicomponent synthesis of β-hydroxy-1,2,3-triazoles from a variety of epoxides and alkynes in water. The catalyst is easy to prepare, reusable at a low copper loading (0.5 mol %), and exhibits higher catalytic activity than some commercially available copper sources. The regio- and stereochemistry of the reaction has been revised and unequivocally established on the basis of X-ray crystallographic analyses. An NMR experiment has been implemented for the rapid and unmistakable determination of the regiochemistry of the process. Some mechanistic aspects of the reaction have been also undertaken which unveil the participation of copper(I) acetylides.
dc.descriptionFil: Alonso, Francisco. Universidad de Alicante; España
dc.descriptionFil: Moglie, Yanina Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.descriptionFil: Radivoy, Gabriel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.descriptionFil: Yus, Miguel. Universidad de Alicante; España
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Chemical Society
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/abs/10.1021/jo2016339
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1021/jo2016339
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subjectCLICK CHEMISTRY
dc.subjectEPOXIDES
dc.subjectTRIAZOLES
dc.subjectCOPPER NANOPARTICLES
dc.subjectREGIOSELECTIVITY
dc.subjecthttps://purl.org/becyt/ford/1.4
dc.subjecthttps://purl.org/becyt/ford/1
dc.titleMulticomponent Click Synthesis of 1,2,3-Triazoles from Epoxides in Water Catalyzed by Copper Nanoparticles on Activated Carbon
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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