dc.creatorAnderson, H. Clarke
dc.creatorHodges, Peter T.
dc.creatorAguillera, Ximena
dc.creatorMissana, Liliana Raquel
dc.creatorMoylan, Paul E.
dc.date2000-12
dc.identifierhttp://hdl.handle.net/11336/78670
dc.identifierAnderson, H. Clarke; Hodges, Peter T.; Aguillera, Ximena; Missana, Liliana Raquel; Moylan, Paul E.; Bone morphogenetic protein (BMP) localization in developing human and rat growth plate, metaphysis, epiphysis and articular cartilage.; Histochemical Society; The Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society; 48; 11; 12-2000; 1493-1502
dc.identifier0022-1554
dc.identifierCONICET Digital
dc.identifierCONICET
dc.descriptionWe assessed the distribution and relative staining intensity of bone morphogenetic protein (BMP)-1–7 by immunohistochemistry in tibial growth plates, epiphyses, metaphyses, and articular cartilage in one 21-week and one 22-week human fetus and in five 10-week-old Sprague–Dawley rats. In the rats, articular cartilage was also examined. BMP proteins were mostly cytoplasmic, with negligible matrix staining. Highest BMP levels were seen in (a) hypertrophic and calcifying zone chondrocytes of growth plate (BMP-1–7), (b) osteoblasts and/or osteoprogenitor fibroblasts and vascular cells of the metaphyseal cortex and medulla (BMP-1–6), (c) osteoclasts of the metaphysis and epiphysis (BMP-1,-4,-5, and −6), and (d) mid to deep zone articular chondrocytes of weanling rats (BMP-1–7). BMP staining in osteoclasts, an unexpected finding, was consistently strong with BMP-4, −5, and −6 but was variable and dependent on osteoclast location with BMP-2,-3, and −7. BMP-1–7 were moderately to intensely stained in vascular canals of human fetal epiphyseal cartilage by endothelial cells and pericytes. BMP-1,-3,-5,-6, and −7 were localized in hypertrophic chondrocytes adjacent to cartilage canals. We conclude that BMP expression is associated with maturing chondrocytes of growth plate and articular cartilage, and may play a role in chondrocyte differentiation and/or apoptosis. BMP appears to be expressed by osteoclasts and might be involved in the intercellular “cross-talk” between osteoclasts and neighboring osteoprogenitor cells at sites of bone remodeling.
dc.descriptionFil: Anderson, H. Clarke. University of Kansas; Estados Unidos
dc.descriptionFil: Hodges, Peter T.. University of Kansas; Estados Unidos
dc.descriptionFil: Aguillera, Ximena. University of Kansas; Estados Unidos
dc.descriptionFil: Missana, Liliana Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina
dc.descriptionFil: Moylan, Paul E.. University of Kansas; Estados Unidos
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherHistochemical Society
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/pdf/10.1177/002215540004801106
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1177%2F002215540004801106
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subjectBone Morphogenetic Protein (Bmp)
dc.subjectGrowth Plate,Metaphysis And Epiphysis
dc.subjectHuman And Rat
dc.subjectArticular Cartilage.
dc.subjecthttps://purl.org/becyt/ford/3.2
dc.subjecthttps://purl.org/becyt/ford/3
dc.titleBone morphogenetic protein (BMP) localization in developing human and rat growth plate, metaphysis, epiphysis and articular cartilage.
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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