Solution thermodynamics of Ibuprofen in aqueous media at pH 1.2 and 6.8

dc.creator	Aragón, Diana M.
dc.creator	Rosas, Jaiver E.
dc.creator	Martínez, Fleming
dc.date	2011
dc.date	2011-12-19T03:00:00Z
dc.identifier	http://sedici.unlp.edu.ar/handle/10915/8365
dc.identifier	http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_9.pdf
dc.description	Based on van't Hoff and Gibbs equations, thermodynamic functions Gibbs energy, enthalpy, and entropy of solution, mixing and solvation of ibuprofen in water at pH 1.2 and 6.8, were evaluated from solubility values determined at several temperatures. The solubility at pH 6.8 and 298.15 K was almost thirty six fold higher with respect to pH 1.2. The enthalpies of solution were positive and greater for pH 6.8 whereas the entropy of solution was negative for pH 1.2 and positive for pH 6.8 finding a greater molecular organization at pH 1.2 after solution process. The results were discussed in terms of solute-solvent interactions
dc.description	Colegio de Farmacéuticos de la Provincia de Buenos Aires
dc.format	application/pdf
dc.format	1720-1727
dc.language	en
dc.relation	Latin American Journal of Pharmacy
dc.relation	vol. 30, no. 9
dc.subject	Farmacia
dc.title	Solution thermodynamics of Ibuprofen in aqueous media at pH 1.2 and 6.8
dc.type	Articulo
dc.type	Articulo