In vitro spermatostatic activity of mulinane- and azorellane-type diterpenes on human spermatozoa

dc.creator	Chiaramello, Alejandra I.
dc.creator	Yunes, Roberto
dc.creator	Rossomando, Pedro
dc.creator	Cifuente, Diego A.
dc.date	2011
dc.date	2011-09-30T03:00:00Z
dc.identifier	http://sedici.unlp.edu.ar/handle/10915/8301
dc.identifier	http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_11.pdf
dc.description	Mulinenic acid (1), mulinolic acid (2) and azorellan- 17,13- (β) olide (3) isolated from Mulinum spinosum and Azorella trifurcata have been evaluated for their spermatostatic activity on human spermatozoa. In vitro sperm motility, viability and recovery of the motility were assessed. Compounds 2 and 3 showed significant spermatostatic properties. Reversible effects for 2 (% Motile Cells = 32 ± 3, % Living Cells = 84 ± 4) and irreversible effects for 3 (% Motile Cells = 34 ± 4, % Living Cells = 82 ± 4) were observed. Compound 1 showed moderate bioactivity. Compounds 2-3 presented remarkable effects on human sperm motility and we were encouraged to consider their application as a potential non hormonal male contraceptive agent.
dc.description	Colegio de Farmacéuticos de la Provincia de Buenos Aires
dc.format	application/pdf
dc.format	1325-1329
dc.language	en
dc.relation	Latin American Journal of Pharmacy
dc.relation	vol. 30, no. 7
dc.subject	Farmacia
dc.title	In vitro spermatostatic activity of mulinane- and azorellane-type diterpenes on human spermatozoa
dc.type	Articulo
dc.type	Articulo