| dc.creator | Yang, Dongzhi | |
| dc.creator | Gao, Yuanyuan | |
| dc.creator | Jiang, Xianglan | |
| dc.creator | Dong, Weifeng | |
| dc.creator | Tang, Daoquan | |
| dc.date | 2011 | |
| dc.date | 2011-06-30T03:00:00Z | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/8253 | |
| dc.identifier | http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_2_6.pdf | |
| dc.description | The pharmacokinetics of lansoprazole after a single intravenous dose of 30 mg was determined in 10 healthy volunteers and 10 peptic ulcers patients. In this work, a liquid-liquid extraction and enrichment method with RP-HPLC determination route was taken with high sensitivity and low limit detection of 5 ng/mL. The concentration-time curves in the two groups were best fitted to a two-compartment model, but their main kinetic parameters were remarkably different between healthy and ulcers volunteers. The mean maximum plasma concentration (C<sub>max</sub> ) and area under the curve (AUC<sub>0t</sub> ) were increased from 975.8 ng/mL to 1298.7 ng/mL and from 1439 ng·h/mL to 2301 ng·h/mL, respectively, and peak time (t<sub>max</sub> ) decreased from 0.36 h to 0.26 h. Meanwhile, the half life (t<sub>1/2</sub> ) prolonged from 2.25 h to 2.91 h and the clearance (CL) reduced from 20.04 L/h to 13.96 L/h. That variability of lansoprazole pharmakinetic parameter indicates that ulcers have significant effect on its metabolic process. | |
| dc.description | Colegio de Farmacéuticos de la Provincia de Buenos Aires | |
| dc.format | application/pdf | |
| dc.format | 1016-1020 | |
| dc.language | en | |
| dc.relation | Latin American Journal of Pharmacy | |
| dc.relation | vol. 30, no. 5 | |
| dc.subject | Farmacia | |
| dc.title | Pharmacokinetics of lansoprazole injection
in peptic ulcer and healthy volunteers | |
| dc.type | Articulo | |
| dc.type | Comunicacion | |
