| dc.creator | Kshirsagar, Sanjay J. | |
| dc.creator | Patel, Smit J. | |
| dc.creator | Madgulkar, Ashwini R. | |
| dc.creator | Bhalekar, Mangesh R. | |
| dc.date | 2011 | |
| dc.date | 2011-05-12T03:00:00Z | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/8218 | |
| dc.identifier | http://www.latamjpharm.org/resumenes/30/4/LAJOP_30_4_2_5.pdf | |
| dc.description | Repaglinide is a potent second generation oral hypoglycaemic agent widely used in treatment
of non insulin dependent diabetic mellitus. The objective of the present study was to develop sustained release microspheres of repaglinide using ethyl cellulose and PEG 6000 as a matrix forming polymer. Microspheres were prepared by taking various concentrations of ethyl cellulose and PEG 6000 by spray drying
technique. Prepared microspheres were evaluated for process yield, drug entrapment, particle size, SEM,
FTIR, DSC and in vitro drug release. Process yield and drug entrapment was 40-45 % and 90-95 %, respectively. Particle size ranged in 5-22 µm and SEM study showed spherical shape and rough surface of
microspheres. FTIR study and DSC analysis revealed the stable nature and amorphous dispersion of drug
in the polymer matrix. In vitro release studies indicate retardation of release upto 12 h which can control
both fasting blood glucose level and postprandial blood glucose. | |
| dc.description | Colegio de Farmacéuticos de la Provincia de Buenos Aires | |
| dc.format | application/pdf | |
| dc.format | 799-803 | |
| dc.language | en | |
| dc.relation | Latin American Journal of Pharmacy | |
| dc.relation | vol. 30, no. 4 | |
| dc.subject | Farmacia | |
| dc.title | Formulation and in-vitro evaluation of repaglinide microspheres prepared by spray drying technique | |
| dc.type | Articulo | |
| dc.type | Comunicacion | |
