Hypromelose / polyethylene oxide (PEO) matrix tablets for oral sustained Aacyclovir release: formulation aspects and release behavior

dc.creatorVechia, Débora D.
dc.creatorBarboza, Fernanda M.
dc.creatorBeltrame, Flávio L.
dc.creatorFraga, Carlos A.
dc.creatorSilva, Marcos A. S.
dc.creatorStulzer, Hellen Karine
dc.date2011
dc.date2011-04-26T03:00:00Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/8166
dc.identifierhttp://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_10.pdf
dc.descriptionHydrophilic matrix tablets were developed with acyclovir (ACV), using hypromelose and polyethylene oxide (PEO) in different concentrations. Matrix tablets obtained in each formulation were evaluated to determine the weight variation, thickness, hardness, drug content, swelling and erosion and in vitro release. The swelling and erosion studies were influenced by pH value and polymer type. The ACV release under acid conditions occurred around 12 and 6 h for PEO and hypromelose matrices, respectively. The mechanism involved in drug release was characterized by anomalous behavior for all formulations, except in 0.1 N HCl where formulations containing hypromelose demonstrated a Super Case II kinetics.
dc.descriptionColegio de Farmacéuticos de la Provincia de Buenos Aires
dc.formatapplication/pdf
dc.format480-486
dc.languageen
dc.relationLatin American Journal of Pharmacy
dc.relationvol. 30, no. 3
dc.subjectFarmacia
dc.titleHypromelose / polyethylene oxide (PEO) matrix tablets for oral sustained Aacyclovir release: formulation aspects and release behavior
dc.typeArticulo
dc.typeArticulo


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