| dc.creator | Rahman, Nisar-ur- | |
| dc.creator | Ahmed, Saeed | |
| dc.creator | Yuen, Kah H. | |
| dc.creator | Sarfraz, Mohammad K. | |
| dc.creator | Akhtar, Muhammad | |
| dc.date | 2010 | |
| dc.date | 2011-01-05T03:00:00Z | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/8072 | |
| dc.identifier | http://www.latamjpharm.org/resumenes/29/8/LAJOP_29_8_1_12.pdf | |
| dc.description | The aim of the present study was to investigate the effects of drug solubility, inert pellet size
and binders used in drug loading on release behavior from Eudragit NE-30 coated pellets. Aqueous solutions
of highly water soluble drugs, diltiazem hydrochloride and chlorpheniramine maleate while hydroalcoholic
solutions of poorly soluble drugs, diclofenac sodium and theophylline were applied onto inert
pellets to produce drug pellets, which were subsequently coated with aqueous polymer dispersion using
bottom spray fluidized-bed coater. Coated pellets were cured at 37 ºC for 24 h prior to dissolution studies.
Drug release from coated pellets using different drugs showed different release profiles. The larger size
pellets displayed significantly slower release rate compared to smaller size pellets. A faster drug release
was achieved with PVP for drug loading in contrast to slower release profile with HPMC. Drug pellets can
be differentiated using scanning electron microscope compared to pellets coated with Eudragit NE-30 | |
| dc.description | Colegio de Farmacéuticos de la Provincia de Buenos Aires | |
| dc.format | application/pdf | |
| dc.format | 1352-1357 | |
| dc.language | en | |
| dc.relation | Latin American Journal of Pharmacy | |
| dc.relation | vol. 29, no. 8 | |
| dc.subject | Farmacia | |
| dc.title | Influence of crug solubility, binders and pellet size in formulating sustained release pellets | |
| dc.type | Articulo | |
| dc.type | Articulo | |
