| dc.creator | Hasan, Raquibul | |
| dc.creator | Hossain, Mokarram | |
| dc.creator | Akter, Raushanara | |
| dc.creator | Jamila, Mariam | |
| dc.creator | Mazumder, Mohammed Ehsanul H. | |
| dc.creator | Islam, Imamul | |
| dc.creator | Faruque, Abdullah | |
| dc.creator | Ghani, Abdul | |
| dc.creator | Rahman, Shafiqur | |
| dc.date | 2009-12-02T03:00:00Z | |
| dc.date | 2009 | |
| dc.date.accessioned | 2017-03-08T20:12:57Z | |
| dc.date.available | 2017-03-08T20:12:57Z | |
| dc.identifier | http://hdl.handle.net/10915/7836 | |
| dc.identifier | http://www.latamjpharm.org/trabajos/28/5/LAJOP_28_5_1_21_432V85WS6A.pdf | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/7836 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/429903 | |
| dc.description | The present study was designed to investigate antioxidant, antidiarrhoeal and cytotoxic potential of hydromethanolic extract of the fruit rind of Punica granatum Linn. A dose dependent scavenging of DPPH radical and NO was observed with significant total antioxidant capacity with the plant extract in 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, total antioxidant capacity and nitric oxide (NO) scavenging assays. The extract was also studied for antidiarrhoeal property using castor oil and MgSO<sub>4</sub> -induced diarrhoeal model, and charcoal induced gastrointestinal motility test in mice. At the doses of 200 and 400 mg/kg body weight, the extract reduced the frequency and severity of diarrhoea in test animals throughout the study period. At the same doses, the extracts significantly (p < 0.001) delayed the intestinal transit of charcoal meal in test animals as compared to the control. The extract also displayed strong cytotoxic potential with LC<sub>50</sub> value of 10 μg/ml in brine shrimp lethality bioassay. | |
| dc.language | en | |
| dc.relation | Latin American Journal of Pharmacy | |
| dc.relation | vol. 28, no. 5 | |
| dc.subject | antioxidante; antidiarreico; citotoxicidad; DPPH; Punica granatum | |
| dc.subject | antioxidant; antidiarrhoeal; cytotoxicity; DPPH; Punica granatum | |
| dc.subject | Farmacia | |
| dc.subject | Farmacología | |
| dc.subject | Extractos de plantas | |
| dc.title | Antioxidant, antidiarrhoeal and cytotoxic properties of Punica granatum Linn | |
| dc.type | Artículos de revistas | |
| dc.type | Artículos de revistas | |
