| dc.creator | Ray, Debajyoti | |
| dc.creator | Mohanta, Guru P. | |
| dc.creator | Gils, P. Sunny | |
| dc.creator | Manavalan, R. | |
| dc.creator | Sahoo, Prafulla K. | |
| dc.date | 2009-12-01T03:00:00Z | |
| dc.date | 2009 | |
| dc.date.accessioned | 2017-03-08T20:12:55Z | |
| dc.date.available | 2017-03-08T20:12:55Z | |
| dc.identifier | http://hdl.handle.net/10915/7831 | |
| dc.identifier | http://www.latamjpharm.org/trabajos/28/5/LAJOP_28_5_1_16_M7IJPD4ANB.pdf | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/7831 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/429898 | |
| dc.description | The present study aims at developing synthesized (PVA-co-PAA)/NaCl normal hydrogel(H), hydrogel microspheres(HM) and comparing the antihypertensive activity of Diltiazem hydrochloride(DL) from two formulations. The hydrogel microspheres were crosslinked by using glutaraldehyde-saturated toluene. The hydrogel showed more swelling in simulated intestinal fluid (SIF). (PVA-co-PAA)/NaCl HM formulation A1 showed comparatively higher entrapment (79%) and better control over DL release. In normotensive rats, HM formulation A1 found more effectively in reducing blood pressure to 40.1%. The experimental results demonstrated that (PVA-co-PAA)/NaCl HM had the greater potential than normal hydrogel to be used as a drug carrier. | |
| dc.language | en | |
| dc.relation | Latin American Journal of Pharmacy | |
| dc.relation | vol. 28, no. 5 | |
| dc.subject | drug delivery; hydrogel microspheres; normal hydrogel; stability; swelling | |
| dc.subject | Farmacia | |
| dc.subject | Farmacología | |
| dc.subject | Medicamentos | |
| dc.title | Delivery of antihypertensive drug through synthesized hydrogel network, a comparative study | |
| dc.type | Artículos de revistas | |
| dc.type | Artículos de revistas | |
