| dc.creator | Barbosa, Nádia R. | |
| dc.creator | Cid, Yara P. | |
| dc.creator | Carvalho, Fernanda L.H. | |
| dc.creator | Ferreira, Aline S. | |
| dc.creator | Silva, Jane A. | |
| dc.date | 2009-06-24T03:00:00Z | |
| dc.date | 2009 | |
| dc.date.accessioned | 2017-03-08T20:12:32Z | |
| dc.date.available | 2017-03-08T20:12:32Z | |
| dc.identifier | http://hdl.handle.net/10915/7760 | |
| dc.identifier | http://www.latamjpharm.org/trabajos/28/2/LAJOP_28_2_2_4_8919RZR280.pdf | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/7760 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/429827 | |
| dc.description | A High-Performance Liquid Chromatography method was developed for quantification of benzalkonium chloride (BAC) and separation of three major homologues, in nasal preparations. Chromatography separation was carried out on a CLC-cyano column, using 0.075M acetate buffer with acetonitrile (45:55, v/v) pH = 5.0, as mobile phase, in an isocratic elution. The total run time was 20 min at a flow rate of 1.0 mL/min. The retention times were of 10.0, 12.8 and 16.1 min, respectively, for homologs C12 , C14 and C16 of benzalkonium chloride. About precision, the method presented excellent repeatability and satisfactory precision intermediate, and the coefficients of variation found were 1.73 and 4.51%, respectively. The accuracy values were ranging from 100.86 to 110.99%. The lower limits of quantification and detection were 5 μg/mL and 2.5 μg/mL, respectively. Two out of seven analyzed lots contained less BAC than allowed. | |
| dc.language | en | |
| dc.relation | Latin American Journal of Pharmacy | |
| dc.relation | vol. 28, no. 2 | |
| dc.subject | benzalkonium chloride; high performance liquid chromatography; pharmaceutical preparations | |
| dc.subject | Farmacia | |
| dc.subject | Preparaciones farmacéuticas | |
| dc.subject | Cromatografia líquida de alta eficiencia | |
| dc.subject | Química Farmacéutica | |
| dc.title | Simple high performance liquid chromatography method for determination of benzalkonium chloride homologues in nasal preparations | |
| dc.type | Artículos de revistas | |
| dc.type | Artículos de revistas | |
