| dc.creator | Hosmani, Avinash H. | |
| dc.creator | Kasture, Pramod V. | |
| dc.date | 2009-06-23T03:00:00Z | |
| dc.date | 2009 | |
| dc.date.accessioned | 2017-03-08T20:12:31Z | |
| dc.date.available | 2017-03-08T20:12:31Z | |
| dc.identifier | http://hdl.handle.net/10915/7754 | |
| dc.identifier | http://www.latamjpharm.org/trabajos/28/2/LAJOP_28_2_1_13_JOK94G603E.pdf | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/7754 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/429821 | |
| dc.description | The purpose of the research was to prepare controlled release glipizide mucoadhesive microspheres with a coat consisting of sodium alginate and a mucoadhesive polymer Carbopol 971P. Orificeionic gelation method by using 3<sup>2</sup> factorial design were investigated with a view to develop mucoadhesive microspheres of controlled release. The resulting microspheres were discrete, free flowing, spherical and multinucleate monolithic type. Microencapsulation efficiency was in the range of 56-88%. Microspheres exhibit good mucoadhesive property in the falling film test. Glipizide release from the mucoadhesive microspheres was slow and extended over long period of time. Drug release was non-Fickian type. The concentration of carbopol 971P and sodium alginate had a more significant effect on different variables. In-vivo testing demonstrated a significant hypoglycemic effect of glipizide | |
| dc.language | en | |
| dc.relation | Latin American Journal of Pharmacy | |
| dc.relation | vol. 28, no. 2 | |
| dc.subject | factorial design; glipizide; mucoadhesive microspheres | |
| dc.subject | Farmacia | |
| dc.subject | Productos químicos y drogas | |
| dc.title | Preparation and in vitro and in vivo evaluation of glipizide mucoadhesive microspheres using factorial design | |
| dc.type | Artículos de revistas | |
| dc.type | Artículos de revistas | |
