| dc.creator | Silvério, Alessandra C.P. | |
| dc.creator | Urias, Tatiane S. | |
| dc.creator | Martins, Isarita | |
| dc.creator | Siqueira, Maria E.P.B. | |
| dc.date | 2009-06-12T03:00:00Z | |
| dc.date | 2008 | |
| dc.date.accessioned | 2017-03-08T20:12:10Z | |
| dc.date.available | 2017-03-08T20:12:10Z | |
| dc.identifier | http://hdl.handle.net/10915/7689 | |
| dc.identifier | http://www.latamjpharm.org/resumenes/27/5/LAJOP_27_5_2_4.pdf | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/7689 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/429756 | |
| dc.description | Diazepam, a benzodiazepine drug, has many therapeutic uses but little is known about the diazepam dose/plasma level ratio when the drug is administered for a long period of time. In the present study we determined plasma diazepam concentration in 26 patients receiving 5 and 10 mg/day of the drug.
A gas chromatography/electron-capture detector method was validated for diazepam quantification in plasma using an OV 17-3% in Chromosorb W 80/100 mesh column. The use of 70:30 n-hexane: dichoromethane (v/v) as extraction solvent yielded good results. The following data were obtained: linearity from 10 to 1000 ng mL–1, detection and quantification limits of 5 and 10 ng.mL–1, respectively; intra and interassay average precision of 4.6 and 7.9%, respectively, mean recovery of 80.6%. The drug remained stable in the plasma sample for at least 30 days when stored at -20 °C. The relation between dose and plasma concentration did not increase in linearity when the dose was increased. | |
| dc.language | en | |
| dc.relation | Latin American Journal of Pharmacy | |
| dc.relation | vol. 27, no. 5 | |
| dc.subject | Diazepam; drug monitoring; gas chromatography; plasmatic concentration | |
| dc.subject | Farmacia | |
| dc.subject | Farmacología | |
| dc.subject | Efectos fisiológicos de las drogas | |
| dc.subject | Evaluación de drogas | |
| dc.title | Correlation between Diazepam in plasma and dose in patients in long-term treatment | |
| dc.type | Artículos de revistas | |
| dc.type | Comunicacion | |
