Se investigó la toxicidad, actividad anti-inflamatória, anti-úlcera, anti-hiperglucemiante, hipoglucemiante y anti-hiperlipidémica del extracto hidroalcohólico de tallo (sin corteza) de Picrasma crenata (Vell.) Engler (Simaroubaceae). El extracto presentó baja toxicidad en ratones. Además, de acuerdo al uso popular de esta espécie en el tratamiento de la gastritis y de la diabetes mellitus, se observo um efecto anti-úlcera e hipoglucemiante en ratas. Sin embargo, no fue observado ningún efecto anti-inflamatório, anti-hiperglucémico ni anti-hiperlipidámico en estos animales.The toxicity and the anti-inflammatory, anti-ulcer, anti-hyperglycemic, hypoglycemic and anti-hyperlipidemic effect of the hydroalcoholic extract from woods (without bark) of Picrasma crenata (Vell.) Engler (Simaroubaceae) were investigated. The extract showed low toxicity in mice. Additionally, in agreement with the popular use to treat gastric ulcer and diabetes, anti-ulcer and blood glucose lowering effect were detected in rats. However, anti-inflammatory, anti-hyperglycemic and anti-hyperlipidemic effects were not observed in these animals.