Atividades antimicrobiana e antioxidante e toxicidade de <i>Eugenia uniflora</i>
Antimicrobial and antioxidant activities and toxicity of Eugenia uniflora
| dc.creator | Auricchio, Mariángela T. | |
| dc.creator | Bugno, Adriana | |
| dc.creator | Barros, Silvia B. M. | |
| dc.creator | Bacchi, Elfriede Marianne | |
| dc.date | 2008-11-13T02:00:00Z | |
| dc.date | 2007 | |
| dc.date.accessioned | 2017-03-08T20:10:54Z | |
| dc.date.available | 2017-03-08T20:10:54Z | |
| dc.identifier | http://hdl.handle.net/10915/7443 | |
| dc.identifier | http://www.latamjpharm.org/resumenes/26/1/LAJOP_26_1_1_13.pdf | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/7443 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/429510 | |
| dc.description | A espécie Eugenia uniflora L., planta arbustiva da família Myrtaceae, ocorre em todo o Brasil e na América Latina, desde o México até a Argentina. No extrato hidroalcoólico foi verificada a presença de flavonóides e taninos (20,06%). O extrato demonstrou atividade antimicrobiana mais expressiva frente a Staphylococcus aureus, Salmonela cholerasuis e Pseudomonas aeruginosa, com CIM de 80 µg/mL; 100 µg/mL e 400 µg/mL, respectivamente. Frente a Candida albicans o extrato exibiu CIM de 500 µg/mL. A atividade antioxidante in vitro do extrato hidroetanólico de folhas de Eugenia uniflora foi determinada pela inibição da autoxidação espontânea em homogenato de cérebro, medida pela técnica do malonildialdeí- do (MDA), sendo o Q1/2 de 34,6 µg/mL. A DL50 do extrato hidroalcoólico das folhas de Eugenia uniflora foi de 5,93 g/kg em camundongos, após administração por via oral. | |
| dc.description | Eugenia uniflora L. (Myrtaceae) is a shrub, which grows all over Latin America from Mexico to Argentina. The extract of Eugenia uniflora leaves showed positive reaction for flavonoids and tannins. Concerning antimicrobial activity, the most susceptible bacteria to Eugenia uniflora leaf extract were Staphylococcus aureus, Salmonela cholerasuis and Pseudomonas aeruginosa, with Minimum Inhibitory Concentration (MIC) of 80, 100 and 400 µg/mL, respectively. The MIC against Candida albicans was 400 µg/mL. The in vitro antioxidant activity of the hydroalcoholic extract from Eugenia uniflora was based on the inhibition of spontaneous lipid peroxidation of rats brain homogenates. Malonyldialdehyde (MDA) was employed as parameter for lipid peroxidation evaluation. Q1/2 was calculated as 34.6 µg/mL. The LD50 of E. uniflora hydroalcoholic extract, orally administered, was 5.93 g/kg. | |
| dc.language | pt | |
| dc.relation | Latin American Journal of Pharmacy | |
| dc.relation | vol. 26, no. 1 | |
| dc.subject | antimicrobiano; eugenia uniflora; toxicidade | |
| dc.subject | antimicrobial; eugenia uniflora; toxicity | |
| dc.subject | Farmacia | |
| dc.subject | Farmacología | |
| dc.subject | Antioxidantes | |
| dc.subject | Tests de toxicidad | |
| dc.title | Atividades antimicrobiana e antioxidante e toxicidade de <i>Eugenia uniflora</i> | |
| dc.title | Antimicrobial and antioxidant activities and toxicity of Eugenia uniflora | |
| dc.type | Artículos de revistas | |
| dc.type | Artículos de revistas |