Nuevos análogos de la cloroquina como agentes antivirales
New chloroquine analogues as antiviral agents
| dc.creator | Dias, Luiza R. S. | |
| dc.creator | Freitas, Antonio C. C. | |
| dc.creator | Nanayakkara, Dhammikka | |
| dc.creator | McChesney, James D. | |
| dc.creator | Walker, Larry | |
| dc.date | 2008-11-06T02:00:00Z | |
| dc.date | 2006 | |
| dc.date.accessioned | 2017-03-08T20:07:58Z | |
| dc.date.available | 2017-03-08T20:07:58Z | |
| dc.identifier | http://hdl.handle.net/10915/6845 | |
| dc.identifier | http://www.latamjpharm.org/trabajos/25/3/LAJOP_25_3_1_5_5MRF4423G7.pdf | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/6845 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/428912 | |
| dc.description | Rinovirus y Enterovirus (polio, coxsackie, echovirus) son los dos tipos de picornavirus responsables del alto número de infecciones virales en humanos como el resfrío (o la gripe). Datos de Relación Estructura Actividad sobre antivirales indica que los heterociclos nitrogenados están presentes en la mayoría de los compuestos activos. Considerando la actividad antiviral de cloroquina, usada como droga estándar para el Coxsackievirus B-3, se sintetizaron y evaluaron dos análogos como agentes antivirales: N<sup>4</sup>-(3-metil-1-fenil-1H-pyrazolo[3,4-b]piridina)-N<sup>1</sup>,N<sup>1</sup>-dietil-1,4-pentanediamina [1] y N<sup>4</sup>-(quinaldina)-N1,N1-dietil-1,4-pentanediamina [2]. El compuesto [1] mostró actividad in vitro contra Coxsackievirus. | |
| dc.description | Rhinoviruses and Enteroviruses (polio, coxsackie, echovirus) are the two types of picornaviruses responsible for the high number of human viral infections as the common cold. Structure Activity Relationship data about antiviral agents indicate the nitrogened heterocycles are present in several active compounds. Considering the antiviral activity of chloroquine, used as standard drug for the Coxsackievirus B-3, two new analogues were synthesized and evaluated as antiviral agents: N<sup>4</sup>-(3-methyl-1-phenyl- 1H-pyrazolo[3,4-b]pyridine)-N<sup>1</sup>,N<sup>1</sup>-diethyl-1,4-pentanediamine [1] and N<sup>4</sup>-(quinaldine)-N<sup>1</sup>,N<sup>1</sup>-diethyl-1,4- pentanediamine [2]. The compound [1] showed in vitro antiviral activity against Coxsackievirus. | |
| dc.language | en | |
| dc.relation | Acta Farmacéutica Bonaerense | |
| dc.relation | vol. 25, no. 3 | |
| dc.subject | antivirales; cloroquina; coxsackievirus; heterociclos | |
| dc.subject | antiviral agents; chloroquine; coxsackievirus; heterocycles | |
| dc.subject | Farmacia | |
| dc.subject | Agentes Antivirales | |
| dc.subject | Quinolinas | |
| dc.title | Nuevos análogos de la cloroquina como agentes antivirales | |
| dc.title | New chloroquine analogues as antiviral agents | |
| dc.type | Artículos de revistas | |
| dc.type | Artículos de revistas |