Investigação do efeito analgésico central e antiinflamatório de conocliniopsis prasiifolia (DC) R.M. King & H. Robinson em roedores
Investigation of central analgesic and anti-inflammatory effect of conocliniopsis prasiifolia (DC) R.M. King & H. Robinson in rodents
| dc.creator | Silva, María das Graças da | |
| dc.creator | Oliveira, Fernando de S. | |
| dc.creator | Quintans Júnior, Lucindo José | |
| dc.creator | Oliveira, Thenio M. L. de | |
| dc.creator | Formiga Melo Diniz, Margareth de Fátima | |
| dc.date | 2008-10-30T02:00:00Z | |
| dc.date | 2005 | |
| dc.date.accessioned | 2017-03-08T20:07:34Z | |
| dc.date.available | 2017-03-08T20:07:34Z | |
| dc.identifier | http://hdl.handle.net/10915/6774 | |
| dc.identifier | http://www.latamjpharm.org/trabajos/24/4/LAJOP_24_4_1_7_8G951498UV.pdf | |
| dc.identifier | http://sedici.unlp.edu.ar/handle/10915/6774 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/428841 | |
| dc.description | El clorhidrato de propranolol (ClPr) es un agente bloqueante β-adrenérgico no selectivo, utilizado principalmente en el tratamiento de la hipertensión, arritmias cardíacas y en angina de pecho y clasificada como de Riesgo Sanitario Intermedio en nuestro país. El objetivo del presente trabajo fue realizar un estudio comparativo de las cinco marcas existentes, de comprimidos conteniendo 40 mg de ClPr, con la finalidad de establecer equivalencia farmacéutica entre ellas. Se realizaron los siguientes ensayos: evaluación de rótulos y prospectos, descripción de los comprimidos, identidad y contenido de ClPr, uniformidad de unidades de dosificación, ensayo de disolución y perfiles de disolución. Se concluyó que no todas las especialidades medicinales conteniendo ClPr 40 mg, en su forma farmacéutica comprimidos, a la fecha del presente estudio, son equivalentes farmacéuticos | |
| dc.description | Propranolol Hydrochloride is a β-adrenergic blocker agent used to treat hypertension, cardiac arrhythmias and angina pectoris and it is classified as a medium risk drug in our country. The aim of this study was to compare the five products present in the argentine market containing ClPr 40 mg (tablets), looking to the pharmaceutical equivalence between them. The following tests were made: evaluation of packaging specifications, description of tablets, identification and quantification, uniformity of dosage units, dissolution test and dissolution profiles. We conclude that there is not pharmaceutical equivalence between all the studied products at the moment of the present study. | |
| dc.language | pt | |
| dc.relation | Acta Farmacéutica Bonaerense | |
| dc.relation | vol. 24, no. 4 | |
| dc.subject | conocliniopsis prasiifolia; efeito analgésico central; efeito antiinflamatório; teste da placa quente; teste do edema de orelha; teste do edema de pata | |
| dc.subject | anti-inflammatory effect; carrageenan-induced paw edema test; central analgesic effect; conocliniopsis prasiifolia; hot plate test; PMA-induced mice ear edema test | |
| dc.subject | Farmacia | |
| dc.title | Investigação do efeito analgésico central e antiinflamatório de conocliniopsis prasiifolia (DC) R.M. King & H. Robinson em roedores | |
| dc.title | Investigation of central analgesic and anti-inflammatory effect of conocliniopsis prasiifolia (DC) R.M. King & H. Robinson in rodents | |
| dc.type | Artículos de revistas | |
| dc.type | Artículos de revistas |