Expression of key steroidogenic enzymes in developing brain: hormonal compensation of sex chromosomes-induced sex differences

dc.creatorCisternas, Carla Daniela
dc.creatorTomé, Karina
dc.creatorCambiasso, María Julia
dc.date.accessioned2021-12-09T16:17:58Z
dc.date.accessioned2022-10-14T18:13:29Z
dc.date.available2021-12-09T16:17:58Z
dc.date.available2022-10-14T18:13:29Z
dc.date.created2021-12-09T16:17:58Z
dc.date.issued2014
dc.identifierhttp://hdl.handle.net/11086/21946
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4266877
dc.description.abstractDeveloping brain of mammals is organized by gonadal steroids during the critical period of sexual differentiation (E18-PN10). The regulatory role of neurosteroids in the early brain is unclear. It is known that 17-β-estradiol (E2) is produced within the brain itself primarily due to local aromatization of gonadal testosterone and also due to de novo synthesis from cholesterol. Little is known about the circulating and local levels of steroids in the embryonic brain. Thus, the use of animal models that dissociate the effect of gonadal sex from sex chromosomes heritage facilitates the study of organizational actions of gonadal steroids and neurosteroids in each sex.
dc.languageeng
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International
dc.subjectAromatasa
dc.subjectCerebro
dc.subjectCromosomas
dc.titleExpression of key steroidogenic enzymes in developing brain: hormonal compensation of sex chromosomes-induced sex differences
dc.typeconferenceObject


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