Chronic omega-3 polyunsaturated fatty acid treatment variably affects cellular repolarization in a healed post-MI arrhythmia model

dc.creatorBonilla, Ingrid M.
dc.creatorNishijima, Yoshinori
dc.creatorVargas-Pinto, Pedro
dc.creatorBaine, Stephen H.
dc.creatorSridhar, Arun
dc.creatorLi, Chun
dc.creatorBillman, George E.
dc.creatorCarnes, Cynthia A.
dc.date2016-06-14T07:00:00Z
dc.date.accessioned2022-10-13T13:38:00Z
dc.date.available2022-10-13T13:38:00Z
dc.identifierhttps://ciencia.lasalle.edu.co/scopus_unisalle/368
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/4158162
dc.descriptionIntroduction: Over the last 40 years omega-3 polyunsaturated fatty acids (PUFAs) have been shown to be anti-arrhythmic or pro-arrhythmic depending on the method and duration of administration and model studied. We previously reported that omega-3 PUFAs do not confer anti-arrhythmic properties and are pro-arrhythmic in canine model of sudden cardiac death (SCD). Here, we evaluated the effects of chronic omega-3 PUFA treatment in post-MI animals susceptible (VF+) or resistant (VF-) to ventricular tachyarrhythmias. Methods: Perforated patch clamp techniques were used to measure cardiomyocyte action potential durations (APD) at 50 and 90% repolarization and short term variability of repolarization. The early repolarizing transient outward potassium current I was also studied. Results: Omega-3 PUFAs prolonged the action potential in VF- myocytes at both 50 and 90% repolarization. Short term variability of repolarization was increased in both untreated and treated VF- myocytes vs. controls. I was unaffected by omega-3 PUFA treatment. Omega-3 PUFA treatment attenuated the action potential prolongation in VF+ myocytes, but did not return repolarization to control values. Conclusions: Omega-3 PUFAs do not confer anti-arrhythmic properties in the setting of healed myocardial infarction in a canine model of SCD. In canines previously resistant to ventricular fibrillation (VF-), omega-3 PUFA treatment prolonged the action potential in VF- myocytes, and may contribute to pro-arrhythmic responses. to to
dc.sourceFrontiers in Physiology
dc.subjectElectrophysiology
dc.subjectMyocardial infarction
dc.subjectOmega-3 polyunsaturated fatty acids
dc.subjectPotassium current
dc.subjectVentricular fibrillation
dc.titleChronic omega-3 polyunsaturated fatty acid treatment variably affects cellular repolarization in a healed post-MI arrhythmia model
dc.typeArticle


Este ítem pertenece a la siguiente institución