dc.contributor | Libra Fdn | |
dc.contributor | Clin El Avila | |
dc.contributor | Univ Antiquia | |
dc.contributor | Univ Santo Amaro | |
dc.contributor | Universidade Federal de São Paulo (UNIFESP) | |
dc.contributor | Univ Hosp | |
dc.contributor | Hosp San Bernardo | |
dc.contributor | Nuevo Hosp San Roque | |
dc.contributor | Univ Cincinnati | |
dc.contributor | Fdn Valle Lili | |
dc.contributor | Consultorios San Juan | |
dc.contributor | Hosp Mocel | |
dc.contributor | Univ Nacl La Plata | |
dc.contributor | Hosp Kennedy | |
dc.creator | Jose Jares, Edgardo | |
dc.creator | Sanchez-Borges, Mario | |
dc.creator | Cardona-Villa, Ricardo | |
dc.creator | Ensina, Luis Felipe [UNIFESP] | |
dc.creator | Arias-Cruz, Alfredo | |
dc.creator | Gomez, Maximiliano | |
dc.creator | Barayazarra, Susana | |
dc.creator | Bernstein, Jonathan A. | |
dc.creator | Serrano, Carlos D. | |
dc.creator | Noemi Cuello, Mabel | |
dc.creator | Maria Morfin-Maciel, Blanca | |
dc.creator | De Falco, Alicia | |
dc.creator | Cherrez-Ojeda, Ivan | |
dc.creator | Latin Amer Drug Allergy Interest G | |
dc.date.accessioned | 2016-01-24T14:37:47Z | |
dc.date.accessioned | 2022-10-07T21:32:10Z | |
dc.date.available | 2016-01-24T14:37:47Z | |
dc.date.available | 2022-10-07T21:32:10Z | |
dc.date.created | 2016-01-24T14:37:47Z | |
dc.date.issued | 2014-09-01 | |
dc.identifier | Annals of Allergy Asthma & Immunology. New York: Elsevier B.V., v. 113, n. 3, p. 282-289, 2014. | |
dc.identifier | 1081-1206 | |
dc.identifier | http://repositorio.unifesp.br/handle/11600/38151 | |
dc.identifier | 10.1016/j.anai.2014.06.019 | |
dc.identifier | WOS:000341301500011 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/4029898 | |
dc.description.abstract | Background: Epidemiologic drug allergy data from Latin America are scarce, and there are no studies on specific procedures focusing on this topic in Latin America.Objective: To assess the clinical characteristics and management of hypersensitivity drug reactions in different Latin American countries.Methods: An European Network of Drug Allergy questionnaire survey was implemented in 22 allergy units in 11 Latin American countries to report on consecutive patients who presented with a suspected hypersensitivity drug reaction. Each unit used its own protocols to investigate patients.Results: Included were 868 hypersensitivity drug reactions in 862 patients (71% of adults and elderly patients were women and 51% of children were girls, P < .0001). Children presented with less severe reactions than adults and elderly patients (P < .0001). Urticaria and angioedema accounted for the most frequent clinical presentations (71%), whereas anaphylaxis was present in 27.3% of cases. There were no deaths reported. Nonsteroidal anti-inflammatory drugs (52.3%), beta-lactam antibiotics (13.8%), and other antibiotics (10.1%) were the drugs used most frequently. Skin prick tests (16.7%) and provocation tests (34.2%) were the study procedures most commonly used. A large proportion of patients were treated in the emergency department (62%) with antihistamines (68%) and/or corticosteroids (53%). Only 22.8% of patients presenting with anaphylaxis received epinephrine.Conclusion: Nonsteroidal anti-inflammatory drugs and antibiotics were the drugs used in at least 75% of patients. More than half the reactions were treated in the emergency department, whereas epinephrine was administered in fewer than 25% of patients with anaphylaxis. Dissemination of guidelines for anaphylaxis among primary and emergency department physicians should be encouraged. (C) 2014 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved. | |
dc.language | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation | Annals of Allergy Asthma & Immunology | |
dc.rights | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dc.rights | Acesso restrito | |
dc.title | Multinational experience with hypersensitivity drug reactions in Latin America | |
dc.type | Artigo | |