GLYCOSAMINOGLYCANS AND PROTEOGLYCANS IN PALMAR FASCIA OF PATIENTS WITH DUPUYTREN

dc.creatorHirai Nascimento, Priscilla Carneiro [UNIFESP]
dc.creatorKobayashi, Elsa Yoko [UNIFESP]
dc.creatorde Saboya Lenzi, Luiz Guilherme [UNIFESP]
dc.creatorGomes dos Santos, Joao Baptista [UNIFESP]
dc.creatorNader, Helena Bonciani [UNIFESP]
dc.creatorFaloppa, Flavio [UNIFESP]
dc.date.accessioned2020-08-21T17:00:08Z
dc.date.accessioned2022-10-07T21:30:59Z
dc.date.available2020-08-21T17:00:08Z
dc.date.available2022-10-07T21:30:59Z
dc.date.created2020-08-21T17:00:08Z
dc.date.issued2016
dc.identifierActa Ortopedica Brasileira. Sao Paulo Sp, v. 24, n. 2, p. 98-101, 2016.
dc.identifier1413-7852
dc.identifierhttps://repositorio.unifesp.br/handle/11600/57881
dc.identifierS1413-78522016000200098-en.pdf
dc.identifierS1413-78522016000200098
dc.identifier10.1590/1413-785220162402154342
dc.identifierWOS:000372326500008
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4029743
dc.description.abstractObjective: To evaluate and compare the behavior of glycosaminoglycans (GAGs) in Dupuytren disease (DD). Methods: This is an experimental study with 23 patients diagnosed with DD. Tissue collected through fasciectomy with incision type Brunner or McCash were evaluated by electrophoresis for identification of GAGs. The quantification was carried out by immunofluorescence and dosage of proteins for different types of glycosaminoglycans. The results were expressed in percentage and statistically evaluated. Results: A significant increase was observed through eletrophoresis in GAGs, as compared to the control (p<0.05). Immunofluorescence of hyaluronic acid was reduced (23 times) when compared to the control (p<0.0001). Conclusion: An increase of sulfated GAGs in Dupuytren's disease, mainly dermatan sulfate, was evident from our results, as well as a pronounced decrease of hyaluronic acid in the palmar aponeurosis from the same patients.
dc.languageeng
dc.publisherAtha Comunicacao & Editora
dc.relationActa Ortopedica Brasileira
dc.rightsAcesso aberto
dc.subjectDupuytren contracture
dc.subjectGlycosaminoglycans
dc.subjectProteoglycans
dc.subjectFascia
dc.titleGLYCOSAMINOGLYCANS AND PROTEOGLYCANS IN PALMAR FASCIA OF PATIENTS WITH DUPUYTREN
dc.typeArtigo


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