Total renal denervation reduces sympathoexcitation to different target organs in a model of chronic kidney disease

dc.creatorVeiga, Glaucia L.[UNIFESP]
dc.creatorNishi, Erika E.[UNIFESP]
dc.creatorEstrela, Heder F.[UNIFESP]
dc.creatorLincevicius, Gisele S.[UNIFESP]
dc.creatorGomes, Guiomar N.
dc.creatorSimoes Sato, Alex Y.[UNIFESP]
dc.creatorCampos, Ruy R.[UNIFESP]
dc.creatorBergamaschi, Cassia T.[UNIFESP]
dc.date.accessioned2020-07-13T11:53:25Z
dc.date.accessioned2022-10-07T21:30:50Z
dc.date.available2020-07-13T11:53:25Z
dc.date.available2022-10-07T21:30:50Z
dc.date.created2020-07-13T11:53:25Z
dc.date.issued2017
dc.identifierAutonomic Neuroscience-Basic & Clinical. Amsterdam, v. 204, p. 81-87, 2017.
dc.identifier1566-0702
dc.identifierhttps://repositorio.unifesp.br/handle/11600/54616
dc.identifier10.1016/j.autneu.2016.11.006
dc.identifierWOS:000400219400010
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4029734
dc.description.abstractIt is known that increased sympathetic nerve activity in chronic kidney disease (CKD) progressively worsens kidney function and hypertension. We tested the hypothesis that total renal denervation contributes to reduce sympathetic activation to different beds and improves renal function in 5/6 nephrectomy model of CKD in male Wistar rats. After eight weeks of 5/6 nephrectomy surgery there was an increase in mean arterial pressure (CKD 179 +/- 22 mm Hg, n = 6 vs. control animals 108 +/- 9
dc.description.abstractp < 0.05, n = 6) with no changes in heart rate (HR). Sympathetic nerve activity was increased at different levels to the remaining kidney, splanchnic and lumbar beds compared to control (CTL) group (CKD rSNA: 150 +/- 50, n = 9 vs. CTL 96 +/- 15, n = 9
dc.description.abstractCKD sSNA: 129 +/- 51, n = 5 vs. CTL 34 +/- 14, n = 6
dc.description.abstractCKD ISNA: 203 +/- 35, n = 8 vs. CTL 146 +/- 21, spikes/s, n = 7, p < 0.05). Three weeks after total renal denervation (DNX) MAP was normalized in the CKD rats (124 +/- 19 mm Hg, n = 5, p < 0.05), with no change in HR. The ISNA was normalized (151 +/- 40, n = 5, vs. CKD 203 +/- 35 spikes/s, n = 8) and sSNA was decreased in 49% (64 +/- 34, n = 5 vs. CKD 129 +/- 51 spikes/s, n = 5, p < 0.05). Renal function, assessed by creatinine plasma levels was improved after renal denervation (CKD 1.50 +/- 0.64, n = 8
dc.description.abstractvs. CKD + DNX 0.82 +/- 0.22 mg/mL, n = 8, p < 0.05). These findings demonstrate that renal nerves contribute to the maintenance of hypertension in CKD by increasing sympathoexcitation to other beds. (C) 2016 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier Science Bv
dc.relationAutonomic Neuroscience-Basic & Clinical
dc.rightsAcesso restrito
dc.subjectChronic kidney disease
dc.subjectHypertension
dc.subjectSympathetic activity
dc.subjectRenal afferent activation
dc.subjectRenal denervation
dc.titleTotal renal denervation reduces sympathoexcitation to different target organs in a model of chronic kidney disease
dc.typeArtigo


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