Late auditory event-related evoked potential (P300) in Down's syndrome patients

Abstract

Down syndrome is caused by a trisomy of chromosome 21 and is associated with central auditory processing deficit, learning disability and, probably, early-onset Alzheimer's disease. Aim: to evaluate the latencies and amplitudes of evoked late auditory potential related to P300 events and their changes in young adults with Down's syndrome. Materials and Method: Prospective case study. P300 test latency and amplitudes were evaluated in 17 individuals with Down's syndrome and 34 healthy individuals. Results: The P300 latency (N1, P2, N2 and P3) was longer and the N2-P3 amplitude was lower in individuals with Down syndrome when compared to those in the control group. Conclusion: In young adults with Down syndrome, N1, P2, N2 and P3 latencies of late auditory evoked potential related to P300 events were prolonged, and N2 - P3 amplitudes were significantly reduced, suggesting integration impairment between the auditory association area and cortical and subcortical areas of the central nervous system.