dc.contributor | Dante Pazzanese Inst Cardiol | |
dc.contributor | Universidade Federal de São Paulo (UNIFESP) | |
dc.contributor | Univ Tennessee | |
dc.contributor | Karolinska Inst | |
dc.creator | Amparo, Fernanda C. [UNIFESP] | |
dc.creator | Kamimura, Maria Ayako [UNIFESP] | |
dc.creator | Molnar, Miklos Z. | |
dc.creator | Cuppari, Lilian [UNIFESP] | |
dc.creator | Lindholm, Bengt | |
dc.creator | Amodeo, Celso | |
dc.creator | Carrero, Juan J. | |
dc.creator | Cordeiro, Antonio C. | |
dc.date.accessioned | 2016-01-24T14:40:28Z | |
dc.date.accessioned | 2022-10-07T21:29:52Z | |
dc.date.available | 2016-01-24T14:40:28Z | |
dc.date.available | 2022-10-07T21:29:52Z | |
dc.date.created | 2016-01-24T14:40:28Z | |
dc.date.issued | 2015-05-01 | |
dc.identifier | Nephrology Dialysis Transplantation. Oxford: Oxford Univ Press, v. 30, n. 5, p. 821-828, 2015. | |
dc.identifier | 0931-0509 | |
dc.identifier | http://repositorio.unifesp.br/handle/11600/39064 | |
dc.identifier | 10.1093/ndt/gfu380 | |
dc.identifier | WOS:000355315300018 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/4029596 | |
dc.description.abstract | Malnutrition and inflammation are highly prevalent and intimately linked conditions in chronic kidney disease (CKD) patients that lead to a state of protein-energy wasting (PEW), the severity of which can be assessed by the Malnutrition-Inflammation Score (MIS). Here, we applied MIS and validated, for the first time, its ability to grade PEW and predict mortality in nondialyzed CKD patients.We cross-sectionally evaluated 300 CKD stages 3-5 patients [median age 61 (53-68) years; estimated glomerular filtration rate 18 (12-27) mL/min/1.73 m(2); 63% men] referred for the first time to our center. Patients were followed during a median 30 (18-37) months for all-cause mortality.A worsening in MIS scale was associated with inflammatory biomarkers increase (i.e. alpha-1 acid glycoprotein, fibrinogen, ferritin and C-reactive protein) as well as a progressive deterioration in various MIS-independent indicators of nutritional status based on anthropometrics, dynamometry, urea kinetics and bioelectric impedance analysis. A structural equation model with two latent variables (assessing simultaneously malnutrition and inflammation factors) demonstrated good fit to the observed data. During a follow-up, 71 deaths were recorded; patients with higher MIS were at increased mortality risk in both crude and adjusted Cox models.MIS appears to be a useful tool to assess PEW in nondialyzed CKD patients. in addition, MIS identified patients at increased mortality risk. | |
dc.language | eng | |
dc.publisher | Oxford Univ Press | |
dc.relation | Nephrology Dialysis Transplantation | |
dc.rights | http://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html | |
dc.rights | Acesso restrito | |
dc.subject | acute phase response | |
dc.subject | outcomes | |
dc.subject | renal disease | |
dc.subject | undernutrition | |
dc.subject | uremia | |
dc.title | Diagnostic validation and prognostic significance of the Malnutrition-Inflammation Score in nondialyzed chronic kidney disease patients | |
dc.type | Artigo | |