DNA methylation, ageing and ribosomal genes activity

dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorCarvalho, Cristina Valletta de [UNIFESP]
dc.creatorPayão, Spencer Luiz Marques [UNIFESP]
dc.creatorSmith, Marilia de Arruda Cardoso [UNIFESP]
dc.date.accessioned2016-01-24T12:30:59Z
dc.date.available2016-01-24T12:30:59Z
dc.date.created2016-01-24T12:30:59Z
dc.date.issued2000-01-01
dc.identifierBiogerontology. Dordrecht: Kluwer Academic Publ, v. 1, n. 4, p. 357-361, 2000.
dc.identifier1389-5729
dc.identifierhttps://repositorio.unifesp.br/handle/11600/26225
dc.identifier10.1023/A:1026542618182
dc.identifierWOS:000166618300007
dc.description.abstractDNA methylation is an epigenetic mechanism controlling of gene expression. We studied the effect of a demethylation agent 5-azacytidine, on ribosomal gene activity observed by Nucleolus Staining Giemsa in the chromosomes of eight Alzheimer's disease patients, eight elderly healthy individuals and eight young healthy controls. Metaphase cells were obtained from lymphocyte cultures. All the acrocentric chromosome pairs were analyzed using G banding followed by Nucleolus Staining Giemsa banding in the same cell. the Alzheimer's disease patients and elderly healthy control did not show a variation in the transcriptional activity of ribosomal genes with or without 5-azacytidine treatment, whereas the young control group showed an increase in this activity with the treatment.
dc.languageeng
dc.publisherKluwer Academic Publ
dc.relationBiogerontology
dc.rightsAcesso restrito
dc.subjectAgeing
dc.subjectRibosomal genes
dc.subjectAlzheimer's disease
dc.subjectDNA methylation
dc.subjectNucleolus organizer region
dc.titleDNA methylation, ageing and ribosomal genes activity
dc.typeArtigo


Este ítem pertenece a la siguiente institución