Endometrial leukemia inhibitory factor as a predictor of pregnancy after in vitro fertilization

dc.contributorHuntington Reproduct Ctr
dc.contributorUniversidade de São Paulo (USP)
dc.contributorHosp Canc AC Camargo
dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorSerafini, Paulo
dc.creatorRocha, Andre M.
dc.creatorOsorio, Cyntia T.
dc.creatorSilva, Ismael da [UNIFESP]
dc.creatorMotta, Eduardo L. [UNIFESP]
dc.creatorBaracat, Edmund C.
dc.date.accessioned2016-01-24T13:51:30Z
dc.date.accessioned2022-10-07T21:10:13Z
dc.date.available2016-01-24T13:51:30Z
dc.date.available2022-10-07T21:10:13Z
dc.date.created2016-01-24T13:51:30Z
dc.date.issued2008-07-01
dc.identifierInternational Journal of Gynecology & Obstetrics. Clare: Elsevier B.V., v. 102, n. 1, p. 23-27, 2008.
dc.identifier0020-7292
dc.identifierhttp://repositorio.unifesp.br/handle/11600/30760
dc.identifier10.1016/j.ijgo.2007.12.005
dc.identifierWOS:000257613500006
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4027267
dc.description.abstractObjective: To determine whether there is an association between endometrial expression of leukemia inhibitory factor (LIF) in the luteal phase of the menstrual cycle preceding in vitro fertilization (IVF) and treatment outcome. Methods: Biopsy specimens from the endometria of 52 women in the luteal. phase were immunostained against LIF Embryo culture and transfer were done according to standard procedures. Results: Clinical pregnancy occurred in 39% of the women following IVF, and strong endometrial immunohistochemical staining for LIF was associated with pregnancy (P=0.01). the women with a strong LIF expression had a 6.4-fold higher chance of becoming pregnant than those with weaker intensities (P=0.005). Conclusion: Endometrial expression of LIF during the luteal phase can be used as a predictor of IVF success. (C) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationInternational Journal of Gynecology & Obstetrics
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.rightsAcesso restrito
dc.subjectendometrial biopsy
dc.subjectendometrial receptivity
dc.subjectin vitro fertilization
dc.subjectleukemia inhibitory factor
dc.subjectluteal phase
dc.subjecttissue microarray
dc.titleEndometrial leukemia inhibitory factor as a predictor of pregnancy after in vitro fertilization
dc.typeArtigo


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